Inhibition of cocaine self-administration by fluoxetine or D-fenfluramine combined with phentermine

Andrew C. Glatz, Michelle Ehrlich, Richard S. Bae, Michelle J. Clarke, Patricia A. Quinlan, Emily C. Brown, Pedro Rada, Bartley G. Hoebel

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Instrumental responding for intravenous cocaine in rats at 85% of free-feeding weight was significantly decreased 50% by D-fenfluramine plus phentermine (D-Fen/Phen, 5 mg/kg of each for 1 day). A similar effect was obtained in normal-weight rats self-administering a cocaine - heroin mixture. Treating normal-weight animals with fluoxetine (5 mg/kg) for 4 days also significantly decreased cocaine self-administration by half, and then adding phentermine caused an additional decrease in cocaine intake. Animals that were well trained to self-administer drug did not self-administer intravenous D-Fen/Phen or Flu/Phen. The present results confirm that serotonergic drugs can decrease cocaine, or cocaine/heroin, self-administration in rats, and that phentermine adds to the effect. Based on related research with the same dose of D-Fen/Phen, it is suggested that effectiveness in reducing cocaine reinforcement is due in part to a satiating effect in which dopamine and acetylcholine are released in the nucleus accumbens.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalPharmacology Biochemistry and Behavior
Issue number1-2
StatePublished - Jan 2 2002


  • Cocaine
  • D-Fenfluramine
  • Fenfluramine
  • Fluoxetine
  • Heroin
  • Phentermine
  • Rat
  • Self-administration
  • Speedball


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