Inhibition and Brain Work

György Buzsáki, Kai Kaila, Marcus Raichle

Research output: Contribution to journalReview articlepeer-review

306 Scopus citations


The major part of the brain's energy budget (∼60%-80%) is devoted to its communication activities. While inhibition is critical to brain function, relatively little attention has been paid to its metabolic costs. Understanding how inhibitory interneurons contribute to brain energy consumption (brain work) is not only of interest in understanding a fundamental aspect of brain function but also in understanding functional brain imaging techniques which rely on measurements related to blood flow and metabolism. Herein we examine issues relevant to an assessment of the work performed by inhibitory interneurons in the service of brain function.

Original languageEnglish
Pages (from-to)771-783
Number of pages13
Issue number5
StatePublished - Dec 6 2007


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