Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease

Keyphrases

• Autosomal Dominant Polycystic Kidney Disease (ADPKD) 100%
• Kidney Function 100%
• Cystogenesis 100%
• Centrosome Clustering 100%
• Centrosome Amplification 66%
• Apoptosis 33%
• Cyst 33%
• Inflammatory Pathways 33%
• Centrosome 33%
• Mouse Model 16%
• Monogenic 16%
• High Incidence 16%
• Renal Function 16%
• Kidney 16%
• Renal Failure 16%
• Fibrosis 16%
• Cell Viability 16%
• Biogenesis 16%
• Reduced Cell 16%
• Inflammatory Factors 16%
• Ciliary Signaling 16%
• Surveillance System 16%
• Interstitial Fibrosis 16%
• Genomic Instability 16%
• Transcriptional Analysis 16%
• Mitotic Catastrophe 16%
• Growth in Vitro 16%
• Renal Morphology 16%
• Human Cell Models 16%
• Spindle Configuration 16%
• Bipolar Spindle 16%
• Cyst Expansion 16%
• PJ34 16%

Medicine and Dentistry

• Polycystic Kidney Disease 100%
• Kidney Function 100%
• Centrosome 100%
• Programmed Cell Death 16%
• Secretion (Process) 8%
• In Vitro 8%
• Fibrosis 8%
• Protein P53 8%
• Genomic Instability 8%
• Cell Viability 8%
• Renal Failure 8%
• Cell Signaling Pathway 8%
• Biogenesis 8%
• Idiopathic Pulmonary Fibrosis 8%
• Monogenic Disorder 8%
• N (5,6 Dihydro 6 Oxo 2 Phenanthridinyl) 2 Dimethylaminoacetamide 8%
• Multipolar Spindles 8%