TY - JOUR
T1 - Inheritance of Alcohol Abuse
T2 - Cross-Fostering Analysis of Adopted Men
AU - Cloninger, C. Robert
AU - Bohman, Michael
AU - Sigvardsson, Sören
PY - 1981/8
Y1 - 1981/8
N2 - The inheritance of alcoholism was studied in 862 Swedish men adopted by nonrelatives at an early age. Both the congenital and postnatal backgrounds of the adoptees modify their risk for alcohol abuse. We distinguish two forms of alcoholism that have distinct genetic and environmental causes and differ in their association with criminality, severity of alcohol abuse, and the frequency of expression in biological mothers. Postnatal milieu determines the frequency and severity of expression of the common type of susceptibility in both men and women. In contrast, the less common type is highly heritable in men but is seldom expressed in mothers of affected men.
AB - The inheritance of alcoholism was studied in 862 Swedish men adopted by nonrelatives at an early age. Both the congenital and postnatal backgrounds of the adoptees modify their risk for alcohol abuse. We distinguish two forms of alcoholism that have distinct genetic and environmental causes and differ in their association with criminality, severity of alcohol abuse, and the frequency of expression in biological mothers. Postnatal milieu determines the frequency and severity of expression of the common type of susceptibility in both men and women. In contrast, the less common type is highly heritable in men but is seldom expressed in mothers of affected men.
UR - http://www.scopus.com/inward/record.url?scp=0019466547&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1981.01780330019001
DO - 10.1001/archpsyc.1981.01780330019001
M3 - Article
C2 - 7259422
AN - SCOPUS:0019466547
VL - 38
SP - 861
EP - 868
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
SN - 0003-990X
IS - 8
ER -