Inhaled [13N]nitric oxide: A positron emission tomography (PET) study

Timothy J. McCarthy; Carmen S. Dence; Sandra W. Holmberg; Joanne Markham; Daniel P. Schuster; Michael J. Welch

doi:10.1016/0969-8051(96)00072-8

Inhaled [¹³N]nitric oxide: A positron emission tomography (PET) study

Timothy J. McCarthy
, Carmen S. Dence
, Sandra W. Holmberg
, Joanne Markham
, Daniel P. Schuster
, Michael J. Welch

Division of Radiological Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [¹³N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [¹³N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.

Original language	English
Pages (from-to)	773-777
Number of pages	5
Journal	Nuclear Medicine and Biology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/0969-8051(96)00072-8
State	Published - Aug 1996

Keywords

graphite
lung
nitric oxide
nitrogen-13
positron emission tomography

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10.1016/0969-8051(96)00072-8

Cite this

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title = "Inhaled [13N]nitric oxide: A positron emission tomography (PET) study",

abstract = "Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.",

keywords = "graphite, lung, nitric oxide, nitrogen-13, positron emission tomography",

author = "McCarthy, \{Timothy J.\} and Dence, \{Carmen S.\} and Holmberg, \{Sandra W.\} and Joanne Markham and Schuster, \{Daniel P.\} and Welch, \{Michael J.\}",

note = "Funding Information: Institutes of Health (POI-HL-13851 to M.J.W.; D.P.S.) and The Whitaker Foundation (T.J.M.)",

year = "1996",

month = aug,

doi = "10.1016/0969-8051(96)00072-8",

language = "English",

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T1 - Inhaled [13N]nitric oxide

T2 - A positron emission tomography (PET) study

AU - McCarthy, Timothy J.

AU - Dence, Carmen S.

AU - Holmberg, Sandra W.

AU - Markham, Joanne

AU - Schuster, Daniel P.

AU - Welch, Michael J.

N1 - Funding Information: Institutes of Health (POI-HL-13851 to M.J.W.; D.P.S.) and The Whitaker Foundation (T.J.M.)

PY - 1996/8

Y1 - 1996/8

N2 - Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.

AB - Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.

KW - graphite

KW - lung

KW - nitric oxide

KW - nitrogen-13

KW - positron emission tomography

UR - https://www.scopus.com/pages/publications/0030201171

U2 - 10.1016/0969-8051(96)00072-8

DO - 10.1016/0969-8051(96)00072-8

M3 - Article

C2 - 8940720

AN - SCOPUS:0030201171

SN - 0969-8051

VL - 23

SP - 773

EP - 777

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 6

ER -

Inhaled [¹³N]nitric oxide: A positron emission tomography (PET) study

Abstract

Keywords

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