Inhaled [13N]nitric oxide: A positron emission tomography (PET) study

Timothy J. McCarthy, Carmen S. Dence, Sandra W. Holmberg, Joanne Markham, Daniel P. Schuster, Michael J. Welch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.

Original languageEnglish
Pages (from-to)773-777
Number of pages5
JournalNuclear Medicine and Biology
Volume23
Issue number6
DOIs
StatePublished - Aug 1996

Keywords

  • graphite
  • lung
  • nitric oxide
  • nitrogen-13
  • positron emission tomography

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