Abstract
Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.
Original language | English |
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Pages (from-to) | 773-777 |
Number of pages | 5 |
Journal | Nuclear Medicine and Biology |
Volume | 23 |
Issue number | 6 |
DOIs | |
State | Published - Aug 1996 |
Keywords
- graphite
- lung
- nitric oxide
- nitrogen-13
- positron emission tomography