Informatics at the Frontier of Cancer Research

Kathleen Noller; Taxiarchis Botsis; Pablo G. Camara; Lauren Ciotti; Lee A.D. Cooper; Jeremy Goecks; Malachi Griffith; Brian J. Haas; Trey Ideker; Rachel Karchin; Despina Kontos; Jiaying Lai; Daniel Marcus; Clifford A. Meyer; Kristen Naegle; Sarthak Pati; Bjoern Peters; Dexter Pratt; Benjamin J. Raphael; Michael Reich; Guergana K. Savova; Carrie Wright; Elana J. Fertig; Spyridon Bakas

doi:10.1158/0008-5472.CAN-24-2829

Informatics at the Frontier of Cancer Research

Kathleen Noller, Taxiarchis Botsis, Pablo G. Camara, Lauren Ciotti, Lee A.D. Cooper, Jeremy Goecks, Malachi Griffith, Brian J. Haas, Trey Ideker, Rachel Karchin, Despina Kontos, Jiaying Lai, Daniel Marcus, Clifford A. Meyer, Kristen Naegle, Sarthak Pati, Bjoern Peters, Dexter Pratt, Benjamin J. Raphael, Michael ReichGuergana K. Savova, Carrie Wright, Elana J. Fertig, Spyridon Bakas

Research output: Contribution to journal › Review article › peer-review

Abstract

Digitized healthcare data, high-throughput profiling technologies, and data repositories have facilitated the emergence of a new era of cancer research. Each data stream requires specialized analysis methods for interpretation. The data-driven era of cancer research requires the development, enhancement, and sustainment of informatics technology software infrastructure, including fundamental methodology development in artificial intelligence and data science. We review current and emerging informatics technology developments for cancer research and discovery, spanning molecular and cellular characterizations, image analysis, informatics, and therapeutics. Summarizing the diverse methods and applications of informatics throughout cancer research identifies themes and emerging areas for the next generation of cancer research.

Original language	English
Pages (from-to)	2967-2986
Number of pages	20
Journal	Cancer research
Volume	85
Issue number	16
DOIs	https://doi.org/10.1158/0008-5472.CAN-24-2829
State	Published - Aug 2025

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Noller, K., Botsis, T., Camara, P. G., Ciotti, L., Cooper, L. A. D., Goecks, J., Griffith, M., Haas, B. J., Ideker, T., Karchin, R., Kontos, D., Lai, J., Marcus, D., Meyer, C. A., Naegle, K., Pati, S., Peters, B., Pratt, D., Raphael, B. J., ... Bakas, S. (2025). Informatics at the Frontier of Cancer Research. Cancer research, 85(16), 2967-2986. https://doi.org/10.1158/0008-5472.CAN-24-2829

@article{9a7ed035b72646b684f706f07d751aba,

title = "Informatics at the Frontier of Cancer Research",

abstract = "Digitized healthcare data, high-throughput profiling technologies, and data repositories have facilitated the emergence of a new era of cancer research. Each data stream requires specialized analysis methods for interpretation. The data-driven era of cancer research requires the development, enhancement, and sustainment of informatics technology software infrastructure, including fundamental methodology development in artificial intelligence and data science. We review current and emerging informatics technology developments for cancer research and discovery, spanning molecular and cellular characterizations, image analysis, informatics, and therapeutics. Summarizing the diverse methods and applications of informatics throughout cancer research identifies themes and emerging areas for the next generation of cancer research.",

author = "Kathleen Noller and Taxiarchis Botsis and Camara, \{Pablo G.\} and Lauren Ciotti and Cooper, \{Lee A.D.\} and Jeremy Goecks and Malachi Griffith and Haas, \{Brian J.\} and Trey Ideker and Rachel Karchin and Despina Kontos and Jiaying Lai and Daniel Marcus and Meyer, \{Clifford A.\} and Kristen Naegle and Sarthak Pati and Bjoern Peters and Dexter Pratt and Raphael, \{Benjamin J.\} and Michael Reich and Savova, \{Guergana K.\} and Carrie Wright and Fertig, \{Elana J.\} and Spyridon Bakas",

note = "Publisher Copyright: {\textcopyright}2025 The Authors.",

year = "2025",

month = aug,

doi = "10.1158/0008-5472.CAN-24-2829",

language = "English",

volume = "85",

pages = "2967--2986",

journal = "Cancer research",

issn = "0008-5472",

number = "16",

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Noller, K, Botsis, T, Camara, PG, Ciotti, L, Cooper, LAD, Goecks, J, Griffith, M, Haas, BJ, Ideker, T, Karchin, R, Kontos, D, Lai, J, Marcus, D, Meyer, CA, Naegle, K, Pati, S, Peters, B, Pratt, D, Raphael, BJ, Reich, M, Savova, GK, Wright, C, Fertig, EJ & Bakas, S 2025, 'Informatics at the Frontier of Cancer Research', Cancer research, vol. 85, no. 16, pp. 2967-2986. https://doi.org/10.1158/0008-5472.CAN-24-2829

TY - JOUR

T1 - Informatics at the Frontier of Cancer Research

AU - Noller, Kathleen

AU - Botsis, Taxiarchis

AU - Camara, Pablo G.

AU - Ciotti, Lauren

AU - Cooper, Lee A.D.

AU - Goecks, Jeremy

AU - Griffith, Malachi

AU - Haas, Brian J.

AU - Ideker, Trey

AU - Karchin, Rachel

AU - Kontos, Despina

AU - Lai, Jiaying

AU - Marcus, Daniel

AU - Meyer, Clifford A.

AU - Naegle, Kristen

AU - Pati, Sarthak

AU - Peters, Bjoern

AU - Pratt, Dexter

AU - Raphael, Benjamin J.

AU - Reich, Michael

AU - Savova, Guergana K.

AU - Wright, Carrie

AU - Fertig, Elana J.

AU - Bakas, Spyridon

PY - 2025/8

Y1 - 2025/8

N2 - Digitized healthcare data, high-throughput profiling technologies, and data repositories have facilitated the emergence of a new era of cancer research. Each data stream requires specialized analysis methods for interpretation. The data-driven era of cancer research requires the development, enhancement, and sustainment of informatics technology software infrastructure, including fundamental methodology development in artificial intelligence and data science. We review current and emerging informatics technology developments for cancer research and discovery, spanning molecular and cellular characterizations, image analysis, informatics, and therapeutics. Summarizing the diverse methods and applications of informatics throughout cancer research identifies themes and emerging areas for the next generation of cancer research.

AB - Digitized healthcare data, high-throughput profiling technologies, and data repositories have facilitated the emergence of a new era of cancer research. Each data stream requires specialized analysis methods for interpretation. The data-driven era of cancer research requires the development, enhancement, and sustainment of informatics technology software infrastructure, including fundamental methodology development in artificial intelligence and data science. We review current and emerging informatics technology developments for cancer research and discovery, spanning molecular and cellular characterizations, image analysis, informatics, and therapeutics. Summarizing the diverse methods and applications of informatics throughout cancer research identifies themes and emerging areas for the next generation of cancer research.

UR - https://www.scopus.com/pages/publications/105013557388

U2 - 10.1158/0008-5472.CAN-24-2829

DO - 10.1158/0008-5472.CAN-24-2829

M3 - Review article

C2 - 40600473

AN - SCOPUS:105013557388

SN - 0008-5472

VL - 85

SP - 2967

EP - 2986

JO - Cancer research

JF - Cancer research

IS - 16

ER -

Informatics at the Frontier of Cancer Research

Abstract

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