Influenza vaccine after pediatric kidney transplant: A Midwest Pediatric Nephrology Consortium study

Corina Nailescu, Xiyan Xu, Hong Zhou, Henrietta Hall, Amy C. Wilson, Jeffrey D. Leiser, Deepa H. Chand, Rudolph P. Valentini, Diane Hebert, John D. Mahan

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The main aim of this study was to compare the response to trivalent inactivated influenza vaccine in children who received a kidney transplant and were on steroid-free versus steroid-based immunosuppression. Groups: 1. Kidney transplant recipients on steroid-free immunosuppression (n∈=∈27); 2. Kidney transplant recipients on steroid-based immunosuppression (n∈=∈39); 3. Healthy controls (n∈=∈21). Hemagglutination inhibition titers against 2007-2008 A/H1N1 and A/H3N2 and B strains were measured before and 8 weeks postvaccination. Postvaccination geometric mean titers to A/H1N1 were significantly lower among both transplant groups than controls (p∈=∈0.025 and 0.015, respectively). Postvaccination titers to H3N2 and B strains were not statistically different between groups. Proportions of participants developing seroprotection were not different among groups. Both kidney transplant groups seroconverted less than controls for A/H1N1 (p∈=∈0.0002) and were no different from controls for B. For A/H3N2, the steroid-free group had the weakest seroconversion (p∈=∈0.008), possibly due to mycophenolate-enhanced exposure and a younger age. Overall, children after kidney transplantation demonstrated a good serologic response to the inactivated influenza vaccine although somewhat lower than controls. Steroid-free immunosuppression did not seem to present an advantage in antibody response. Data on inactivated influenza vaccine safety and efficacy was collected and demonstrated absence of acute rejection or laboratory-proven influenza for 6 months postvaccination.

Original languageEnglish
Pages (from-to)459-467
Number of pages9
JournalPediatric Nephrology
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

Keywords

  • Children
  • Influenza
  • Kidney
  • Transplantation
  • Vaccination

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    Nailescu, C., Xu, X., Zhou, H., Hall, H., Wilson, A. C., Leiser, J. D., Chand, D. H., Valentini, R. P., Hebert, D., & Mahan, J. D. (2011). Influenza vaccine after pediatric kidney transplant: A Midwest Pediatric Nephrology Consortium study. Pediatric Nephrology, 26(3), 459-467. https://doi.org/10.1007/s00467-010-1729-1