TY - JOUR
T1 - Influenza a virus-induced acute otitis media
AU - Buchman, Craig A.
AU - Doyle, William J.
AU - Skoner, David P.
AU - Post, J. Christopher
AU - Alper, Cuneyt M.
AU - Seroky, James T.
AU - Anderson, Kenneth
AU - Preston, Robert A.
AU - Hayden, Frederick G.
AU - Fireman, Philip
AU - Ehrlich, Garth D.
PY - 1995/11
Y1 - 1995/11
N2 - To better understand the significanceof viral upper respiratory tract infections in the pathogenesis of acute otitis media (OM), 27 adults underwent intranasal inoculation with influenza A virus. Monitoring consisted of antibody titer determination, tympanometry, and otoscopy. Microbiologic analysis consisted of cultures and polymerase chain reaction (PCR)-based detection for influenza A virus, Streptococcus pneumoniae, Haemophilus infiuenzae, and Moraxella catarrhalis. All subjects became infected with the challenge virus. By day 4, 16 (59%) developed middle ear pressures of -100 mm H2O or below and 4 (25%) of them developed OM. One subject (4%) developed purulent OMrequiring myringotomy for pain relief. Middle ear effusion cultures were negative. PCR analysis of that subject’s middle ear effusion and nasal washes were positive for influenza A virus and S. pneumoniae. These findings support a causal role for viral upper respiratory tract infections in the pathogenesis of OM, possibly mediated by middle ear underpressures and viral and bacterial middle ear infection.
AB - To better understand the significanceof viral upper respiratory tract infections in the pathogenesis of acute otitis media (OM), 27 adults underwent intranasal inoculation with influenza A virus. Monitoring consisted of antibody titer determination, tympanometry, and otoscopy. Microbiologic analysis consisted of cultures and polymerase chain reaction (PCR)-based detection for influenza A virus, Streptococcus pneumoniae, Haemophilus infiuenzae, and Moraxella catarrhalis. All subjects became infected with the challenge virus. By day 4, 16 (59%) developed middle ear pressures of -100 mm H2O or below and 4 (25%) of them developed OM. One subject (4%) developed purulent OMrequiring myringotomy for pain relief. Middle ear effusion cultures were negative. PCR analysis of that subject’s middle ear effusion and nasal washes were positive for influenza A virus and S. pneumoniae. These findings support a causal role for viral upper respiratory tract infections in the pathogenesis of OM, possibly mediated by middle ear underpressures and viral and bacterial middle ear infection.
UR - http://www.scopus.com/inward/record.url?scp=0028883440&partnerID=8YFLogxK
U2 - 10.1093/infdis/172.5.1348
DO - 10.1093/infdis/172.5.1348
M3 - Article
C2 - 7594675
AN - SCOPUS:0028883440
SN - 0022-1899
VL - 172
SP - 1348
EP - 1351
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -