@inproceedings{89e2c7624734419a9e0b4aeb79e3b339,
title = "Influences of flow parameters on pressure drop in a patient specific right coronary artery with two stenoses",
abstract = "Blood pressure loss along the coronary arterial length and the local magnitude of the spatial wall pressure gradient (WPG) are important factors for atherosclerosis initiation and intimal hyperplasia development. The pressure drop coefficient (CDP) isdefined as the ratio of mean trans-stenotic pressure drop to proximal dynamic pressure. It is a unique non-dimensional flow resistance parameter useful in clinical practice for evaluating hemodynamic impact of coronary stenosis. It is expected that patients with the same stenosis severity may be at different risk level due to their blood pressure situations. The aim of this study is to numerically examine the dependence of CDP and WPG on flow rate and blood viscosity using a patient-specific atherosclerotic right coronary artery model with two stenoses. Our simulation results indicate that the coronary model with a lower flow rate yields a greater CDP across a stenosis, while the model with a higher flow rate yields a greater pressure drop and a greater WPG. Increased blood viscosity results in a greater CDP. Quantitatively, CDP for each stenosis appears to be a linear function of blood viscosity and a decreasing quadratic function of flow rate. Simulations with varying size and location of the distal stenosis show that the influence of the distal stenosis on the CDP across the proximal stenosis is insignificant. In a right coronary artery segment with two moderate stenoses of the same size, the distal stenosis causes a larger drop of CPD than the proximal stenosis does. A distal stenosis located in a further downstream position causes a larger drop in the CDP.",
keywords = "Blood viscosity, Flow rate, Pressure drop coefficient, Spatial wall pressure gradient",
author = "Biyue Liu and Jie Zheng and Richard Bach and Dalin Tang",
note = "Funding Information: This work is partially supported by a grant from the Simons Foundation (#210082 to Biyue Liu), a sabbatical grant from Monmouth University, NIH grant NIH/NIBIB R01 EB004759, and a Jiangsu Province Science and Technology Agency grant BE2016785. Publisher Copyright: {\textcopyright} Springer International Publishing AG 2017.; 17th International Conference on Computational Science and Its Applications, ICCSA 2017 ; Conference date: 03-07-2017 Through 06-07-2017",
year = "2017",
doi = "10.1007/978-3-319-62392-4_5",
language = "English",
isbn = "9783319623917",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "56--70",
editor = "Beniamino Murgante and Apduhan, {Bernady O.} and Giuseppe Borruso and Elena Stankova and Osvaldo Gervasi and Sanjay Misra and David Taniar and Rocha, {Ana Maria A.C.} and Alfredo Cuzzocrea and Torre, {Carmelo M.}",
booktitle = "Computational Science and Its Applications - ICCSA 2017 - 17th International Conference, 2017",
}