TY - JOUR
T1 - Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster
AU - Lin, Yiing
AU - Han, Mei
AU - Shimada, Brian
AU - Wang, Lin
AU - Gibler, Therese M.
AU - Amarakone, Aloka
AU - Awad, Tarif A.
AU - Stormo, Gary D.
AU - Van Gelder, Russell N.
AU - Taghert, Paul H.
PY - 2002/7/9
Y1 - 2002/7/9
N2 - We measured daily gene expression in heads of control and period mutant Drosophila by using oligonucleotide microarrays. In control flies, 72 genes showed diurnal rhythms in light-dark cycles; 22 of these also oscillated in free-running conditions. The period gene significantly influenced the expression levels of over 600 nonoscillating transcripts. Expression levels of several hundred genes also differed significantly between control flies kept in light-dark versus constant darkness but differed minimally between per01 flies kept in the same two conditions. Thus, the period-dependent circadian clock regulates only a limited set of rhythmically expressed transcripts. Unexpectedly, period regulates basal and light-regulated gene expression to a very broad extent.
AB - We measured daily gene expression in heads of control and period mutant Drosophila by using oligonucleotide microarrays. In control flies, 72 genes showed diurnal rhythms in light-dark cycles; 22 of these also oscillated in free-running conditions. The period gene significantly influenced the expression levels of over 600 nonoscillating transcripts. Expression levels of several hundred genes also differed significantly between control flies kept in light-dark versus constant darkness but differed minimally between per01 flies kept in the same two conditions. Thus, the period-dependent circadian clock regulates only a limited set of rhythmically expressed transcripts. Unexpectedly, period regulates basal and light-regulated gene expression to a very broad extent.
UR - http://www.scopus.com/inward/record.url?scp=0037047054&partnerID=8YFLogxK
U2 - 10.1073/pnas.132269699
DO - 10.1073/pnas.132269699
M3 - Article
C2 - 12089325
AN - SCOPUS:0037047054
SN - 0027-8424
VL - 99
SP - 9562
EP - 9567
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 14
ER -