TY - JOUR
T1 - Influence of lifestyle factors on inflammation in men and women with type 2 diabetes
T2 - Results: From the national health and nutrition examination survey, 1999-2004
AU - Jarvandi, Soghra
AU - Davidson, Nicholas O.
AU - Jeffe, Donna B.
AU - Schootman, Mario
N1 - Funding Information:
Acknowledgments SJ was supported by the Washington University School of Medicine. DBJ was supported by the Health Behavior, Communication, and Outreach Core of the Siteman Cancer Center, which is supported in part by the National Cancer Institute Cancer Center Support Grant (P30 CA91842) to the Siteman Cancer Center and the Clinical and Translational Sciences Award (UL1 RR024992) to Washington University School of Medicine. NOD was supported in part by grants from NIH (DK 56260, DK 52574, HL 38180).
PY - 2012/12
Y1 - 2012/12
N2 - Background: Type 2 diabetes is associated with low-grade systemic inflammation, increasing the risk for various adverse health outcomes. Purpose: Our objective was to investigate the association between C-reactive protein (CRP), a marker for systemic inflammation, and lifestyle factors in a national sample of people with type 2 diabetes. Methods: This study analyzed data from 1,086 men and women with diabetes, who completed the 1999-2004 NHANES. Lifestyle factors included diet quality, body mass index (BMI), smoking, and physical activity. Results: Stratified logistic regression showed that for both men and women, BMI was a strong predictor of elevated CRP after adjusting for age, energy intake, race/ethnicity, medications, diabetes duration, and glycosylated hemoglobin. However, among men, but not among women, the likelihood of elevated CRP increased with lower diet quality and physical inactivity. Conclusions: Among people with type 2 diabetes, higher levels of CRP were associated with lower diet quality and physical inactivity among men, and with obesity among both men and women.
AB - Background: Type 2 diabetes is associated with low-grade systemic inflammation, increasing the risk for various adverse health outcomes. Purpose: Our objective was to investigate the association between C-reactive protein (CRP), a marker for systemic inflammation, and lifestyle factors in a national sample of people with type 2 diabetes. Methods: This study analyzed data from 1,086 men and women with diabetes, who completed the 1999-2004 NHANES. Lifestyle factors included diet quality, body mass index (BMI), smoking, and physical activity. Results: Stratified logistic regression showed that for both men and women, BMI was a strong predictor of elevated CRP after adjusting for age, energy intake, race/ethnicity, medications, diabetes duration, and glycosylated hemoglobin. However, among men, but not among women, the likelihood of elevated CRP increased with lower diet quality and physical inactivity. Conclusions: Among people with type 2 diabetes, higher levels of CRP were associated with lower diet quality and physical inactivity among men, and with obesity among both men and women.
KW - C-reactive protein
KW - Inflammation
KW - Lifestyle
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84872276465&partnerID=8YFLogxK
U2 - 10.1007/s12160-012-9397-y
DO - 10.1007/s12160-012-9397-y
M3 - Article
C2 - 22865468
AN - SCOPUS:84872276465
SN - 0883-6612
VL - 44
SP - 399
EP - 407
JO - Annals of Behavioral Medicine
JF - Annals of Behavioral Medicine
IS - 3
ER -