The effects of various agents on the specific tissue binding of 3H naloxone and 3H naltrexone were examined. In addition to the narcotics, α adrenergic blockers and dopamine antagonists also significantly inhibited the specific bindings of these opiates. The binding of naloxone or naltrexone was not significantly altered by β adrenergic blockers, agents which block the effects of acetylcholine, serotonin and histamine at the receptor level, and a number of other drugs. Kinetic analyses revealed that the α adrenergic and dopamine antagonists competitively inhibited the binding of naloxone. The results of these studies provide additional evidence for an interaction between the narcotics and catecholaminergic agents.
|Number of pages||10|
|Journal||Archives Internationales de Pharmacodynamie et de Therapie|
|State||Published - Dec 1 1975|