Influence of catecholaminergic agents on narcotic binding in brain

T. J. Cicero, C. E. Wilcox, E. R. Meyer, H. Michael

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The effects of various agents on the specific tissue binding of 3H naloxone and 3H naltrexone were examined. In addition to the narcotics, α adrenergic blockers and dopamine antagonists also significantly inhibited the specific bindings of these opiates. The binding of naloxone or naltrexone was not significantly altered by β adrenergic blockers, agents which block the effects of acetylcholine, serotonin and histamine at the receptor level, and a number of other drugs. Kinetic analyses revealed that the α adrenergic and dopamine antagonists competitively inhibited the binding of naloxone. The results of these studies provide additional evidence for an interaction between the narcotics and catecholaminergic agents.

Original languageEnglish
Pages (from-to)221-230
Number of pages10
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume218
Issue number2
StatePublished - Dec 1 1975

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