Inflammatory triggers of acute rejection of organ allografts

Daniel N. Mori, Daniel Kreisel, James N. Fullerton, Derek W. Gilroy, Daniel R. Goldstein

Research output: Contribution to journalReview articlepeer-review

107 Scopus citations


Solid organ transplantation is a vital therapy for end stage diseases. Decades of research have established that components of the adaptive immune system are critical for transplant rejection, but the role of the innate immune system in organ transplantation is just emerging. Accumulating evidence indicates that the innate immune system is activated at the time of organ implantation by the release of endogenous inflammatory triggers. This review discusses the nature of these triggers in organ transplantation and also potential mediators that may enhance inflammation resolution after organ implantation.

Original languageEnglish
Pages (from-to)132-144
Number of pages13
JournalImmunological Reviews
Issue number1
StatePublished - Mar 2014


  • Inflammation
  • Organ transplantation
  • Resolution


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