227 Scopus citations

Abstract

Hematopoietic stem cells (HSCs) are the progenitors of all blood and immune cells, yet their role in immunity is not well understood. Most studies have focused on the ability of committed lymphoid and myeloid precursors to replenish immune cells during infection. Recent studies, however, have indicated that HSCs also proliferate in response to systemic infection and replenish effector immune cells. Inflammatory signaling molecules including interferons, tumor necrosis factor-α and Toll-like receptors are essential to the HSC response. Observing the biology of HSCs through the lens of infection and inflammation has led to the discovery of an array of immune-mediators that serve crucial roles in HSC regulation and function.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalTrends in Immunology
Volume32
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Dive into the research topics of 'Inflammatory signals regulate hematopoietic stem cells'. Together they form a unique fingerprint.

Cite this