TY - JOUR
T1 - Inflammatory consequences of inherited disorders affecting neutrophil function
AU - Dinauer, Mary C.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health, National Heart, Lung, and Blood Institute (R01HL045635) and the National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR072212) and by the Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital.
Publisher Copyright:
© 2019 American Society of Hematology. All rights reserved.
PY - 2019/5/16
Y1 - 2019/5/16
N2 - Primary immunodeficiencies affecting the function of neutrophils and other phagocytic leukocytes are notable for an increased susceptibility to bacterial and fungal infections as a result of impaired leukocyte recruitment, ingestion, and/or killing of microbes. The underlying molecular defects can also impact other innate immune responses to infectious and inflammatory stimuli, leading to inflammatory and autoimmune complications that are not always directly related to infection.
AB - Primary immunodeficiencies affecting the function of neutrophils and other phagocytic leukocytes are notable for an increased susceptibility to bacterial and fungal infections as a result of impaired leukocyte recruitment, ingestion, and/or killing of microbes. The underlying molecular defects can also impact other innate immune responses to infectious and inflammatory stimuli, leading to inflammatory and autoimmune complications that are not always directly related to infection.
UR - http://www.scopus.com/inward/record.url?scp=85066918682&partnerID=8YFLogxK
U2 - 10.1182/blood-2018-11-844563
DO - 10.1182/blood-2018-11-844563
M3 - Review article
C2 - 30898864
AN - SCOPUS:85066918682
SN - 0006-4971
VL - 133
SP - 2130
EP - 2139
JO - Blood
JF - Blood
IS - 20
ER -