TY - JOUR
T1 - Inflammatory comorbidities
T2 - to train or not to train?
AU - Bobba, Suhas
AU - Khader, Shabaana A.
N1 - Funding Information:
This work was supported by Washington University in St. Louis School of Medicine to S.A.K.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/6
Y1 - 2022/6
N2 - Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic stem cells (HSCs) in the bone marrow primes cells to generate more inflammatory myeloid progeny and, thereby, mechanistically links inflammatory comorbidities.
AB - Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic stem cells (HSCs) in the bone marrow primes cells to generate more inflammatory myeloid progeny and, thereby, mechanistically links inflammatory comorbidities.
UR - http://www.scopus.com/inward/record.url?scp=85129707012&partnerID=8YFLogxK
U2 - 10.1016/j.it.2022.04.005
DO - 10.1016/j.it.2022.04.005
M3 - Short survey
C2 - 35537982
AN - SCOPUS:85129707012
SN - 1471-4906
VL - 43
SP - 420
EP - 422
JO - Trends in Immunology
JF - Trends in Immunology
IS - 6
ER -