Inflammatory and Immune Mechanisms for Atherosclerotic Cardiovascular Disease in HIV

Laura Hmiel; Suyu Zhang; Laventa M. Obare; Marcela Araujo de Oliveira Santana; Celestine N. Wanjalla; Boghuma K. Titanji; Corrilynn O. Hileman; Shashwatee Bagchi

doi:10.3390/ijms25137266

Inflammatory and Immune Mechanisms for Atherosclerotic Cardiovascular Disease in HIV

Laura Hmiel, Suyu Zhang, Laventa M. Obare, Marcela Araujo de Oliveira Santana, Celestine N. Wanjalla, Boghuma K. Titanji, Corrilynn O. Hileman, Shashwatee Bagchi

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Atherosclerotic vascular disease disproportionately affects persons living with HIV (PLWH) compared to those without. The reasons for the excess risk include dysregulated immune response and inflammation related to HIV infection itself, comorbid conditions, and co-infections. Here, we review an updated understanding of immune and inflammatory pathways underlying atherosclerosis in PLWH, including effects of viral products, soluble mediators and chemokines, innate and adaptive immune cells, and important co-infections. We also present potential therapeutic targets which may reduce cardiovascular risk in PLWH.

Original language	English
Article number	7266
Journal	International journal of molecular sciences
Volume	25
Issue number	13
DOIs	https://doi.org/10.3390/ijms25137266
State	Published - Jul 2024

Keywords

HIV
T lymphocytes
adaptive immune system
atherosclerosis
cardiovascular disease
immune system
inflammation
innate immune system
mechanisms
monocytes/macrophages

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10.3390/ijms25137266

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title = "Inflammatory and Immune Mechanisms for Atherosclerotic Cardiovascular Disease in HIV",

abstract = "Atherosclerotic vascular disease disproportionately affects persons living with HIV (PLWH) compared to those without. The reasons for the excess risk include dysregulated immune response and inflammation related to HIV infection itself, comorbid conditions, and co-infections. Here, we review an updated understanding of immune and inflammatory pathways underlying atherosclerosis in PLWH, including effects of viral products, soluble mediators and chemokines, innate and adaptive immune cells, and important co-infections. We also present potential therapeutic targets which may reduce cardiovascular risk in PLWH.",

keywords = "HIV, T lymphocytes, adaptive immune system, atherosclerosis, cardiovascular disease, immune system, inflammation, innate immune system, mechanisms, monocytes/macrophages",

author = "Laura Hmiel and Suyu Zhang and Obare, {Laventa M.} and Santana, {Marcela Araujo de Oliveira} and Wanjalla, {Celestine N.} and Titanji, {Boghuma K.} and Hileman, {Corrilynn O.} and Shashwatee Bagchi",

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T1 - Inflammatory and Immune Mechanisms for Atherosclerotic Cardiovascular Disease in HIV

AU - Hmiel, Laura

AU - Zhang, Suyu

AU - Obare, Laventa M.

AU - Santana, Marcela Araujo de Oliveira

AU - Wanjalla, Celestine N.

AU - Titanji, Boghuma K.

AU - Hileman, Corrilynn O.

AU - Bagchi, Shashwatee

PY - 2024/7

Y1 - 2024/7

N2 - Atherosclerotic vascular disease disproportionately affects persons living with HIV (PLWH) compared to those without. The reasons for the excess risk include dysregulated immune response and inflammation related to HIV infection itself, comorbid conditions, and co-infections. Here, we review an updated understanding of immune and inflammatory pathways underlying atherosclerosis in PLWH, including effects of viral products, soluble mediators and chemokines, innate and adaptive immune cells, and important co-infections. We also present potential therapeutic targets which may reduce cardiovascular risk in PLWH.

AB - Atherosclerotic vascular disease disproportionately affects persons living with HIV (PLWH) compared to those without. The reasons for the excess risk include dysregulated immune response and inflammation related to HIV infection itself, comorbid conditions, and co-infections. Here, we review an updated understanding of immune and inflammatory pathways underlying atherosclerosis in PLWH, including effects of viral products, soluble mediators and chemokines, innate and adaptive immune cells, and important co-infections. We also present potential therapeutic targets which may reduce cardiovascular risk in PLWH.

KW - HIV

KW - T lymphocytes

KW - adaptive immune system

KW - atherosclerosis

KW - cardiovascular disease

KW - immune system

KW - inflammation

KW - innate immune system

KW - mechanisms

KW - monocytes/macrophages

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U2 - 10.3390/ijms25137266

DO - 10.3390/ijms25137266

M3 - Review article

C2 - 39000373

AN - SCOPUS:85198225562

SN - 1661-6596

VL - 25

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 13

M1 - 7266

ER -

Inflammatory and Immune Mechanisms for Atherosclerotic Cardiovascular Disease in HIV

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