TY - JOUR
T1 - Inflammation Modifies the Association of Obesity with Circulating 25-Hydroxyvitamin D Levels in Cancer Survivors
AU - Yang, Lin
AU - Toriola, Adetunji T.
N1 - Funding Information:
Funding agencies: This work was supported by the Transdisciplinary Research on Energetics and Cancer (TREC) Center at Washington University in St. Louis (LY) and the Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital Foundation, and Washington University School of Medicine (ATT). The TREC Center is funded by the National Cancer Institute at NIH (U54 CA155496). Disclosure: The authors declared no conflict of interest. Author contributions: LY and ATT conceived and designed study, analyzed and interpreted data, and drafted and reviewed manuscript. Received: 28 June 2017; Accepted: 17 August 2017; Published online in Wiley Online Library. doi:10.1002/oby.22011
Publisher Copyright:
© 2017 The Obesity Society
PY - 2017/11
Y1 - 2017/11
N2 - Objective: Obesity, inflammation, and circulating 25-hydroxyvitamin D (25-OHD) have distinct roles in cancer prognosis. The interplay of these factors was investigated by evaluating the associations of body mass index (BMI) with circulating 25-OHD levels in cancer survivors and determining whether associations were modified by inflammation, defined by C-reactive protein (CRP) levels. Methods: Data on cancer survivors were aggregated from the US National Health and Nutrition Examination Survey (2001–2010). Multivariable linear regression models were used to evaluate the associations of BMI with circulating 25-OHD. Analyses were stratified by CRP levels: low < 1.0 mg/L, moderate 1.0-3.0 mg/L, and high > 3.0-9.9 mg/L. Results: Among 1,305 cancer survivors (mean age = 60.8 years, mean BMI = 28.0 kg/m2), circulating 25-OHD levels were 8.74 nmol/L lower (95% CI: 4.71 to 12.77) in cancer survivors with BMI ≥ 30.0 kg/m2 compared with those with BMI < 25.0 kg/m2. This association was, however, limited to those with moderate CRP (−9.90 nmol/L, 95% CI: −16.45 to −3.36) and high CRP (−11.61 nmol/L, 95% CI: −18.71 to −5.05), but not among those with low CRP levels (−5.31 nmol/L, 95% CI:−12.66 to 2.04). Conclusions: A greater understanding of the interplay between 25-OHD and inflammation in cancer survivors with obesity should allow for targeted secondary prevention and help improve prognosis in these patients.
AB - Objective: Obesity, inflammation, and circulating 25-hydroxyvitamin D (25-OHD) have distinct roles in cancer prognosis. The interplay of these factors was investigated by evaluating the associations of body mass index (BMI) with circulating 25-OHD levels in cancer survivors and determining whether associations were modified by inflammation, defined by C-reactive protein (CRP) levels. Methods: Data on cancer survivors were aggregated from the US National Health and Nutrition Examination Survey (2001–2010). Multivariable linear regression models were used to evaluate the associations of BMI with circulating 25-OHD. Analyses were stratified by CRP levels: low < 1.0 mg/L, moderate 1.0-3.0 mg/L, and high > 3.0-9.9 mg/L. Results: Among 1,305 cancer survivors (mean age = 60.8 years, mean BMI = 28.0 kg/m2), circulating 25-OHD levels were 8.74 nmol/L lower (95% CI: 4.71 to 12.77) in cancer survivors with BMI ≥ 30.0 kg/m2 compared with those with BMI < 25.0 kg/m2. This association was, however, limited to those with moderate CRP (−9.90 nmol/L, 95% CI: −16.45 to −3.36) and high CRP (−11.61 nmol/L, 95% CI: −18.71 to −5.05), but not among those with low CRP levels (−5.31 nmol/L, 95% CI:−12.66 to 2.04). Conclusions: A greater understanding of the interplay between 25-OHD and inflammation in cancer survivors with obesity should allow for targeted secondary prevention and help improve prognosis in these patients.
UR - http://www.scopus.com/inward/record.url?scp=85032508053&partnerID=8YFLogxK
U2 - 10.1002/oby.22011
DO - 10.1002/oby.22011
M3 - Article
C2 - 29086515
AN - SCOPUS:85032508053
SN - 1930-7381
VL - 25
SP - S58-S65
JO - Obesity
JF - Obesity
ER -