Inflammation-induced photoreceptor cell death

Abdoulaye Sene, Rajendra S. Apte

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Neuroinflammation is an important aspect of many diseases of the eye, and experimental animal models have been widely used to determine its impact on retinal homeostasis and neuron survival. Physical separation of the neurosensory retina from the underlying retinal pigment epithelium (RPE) results in activation and infiltration of macrophages. Numerous studies have shown the critical role of macrophages in retinal disease processes. In retinal detachment, accumulation of macrophages in the subretinal space is associated with changes in cytokine and chemokine profile which lead to photoreceptor cell death. Targeted disruption of macrophage chemotaxis significantly reduces retinal detachment-induced photoreceptor degeneration. Apoptosis is the predominant mechanism of cell death; however regulated necrosis is also a contributor of photoreceptor loss. Therefore, effective neuroprotective approaches could integrate combined inhibition of both apoptotic and regulated necrosis pathways.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages203-208
Number of pages6
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1074
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Macrophages
  • Neuroinflammation
  • Photoreceptor degeneration
  • Retinal detachment

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  • Cite this

    Sene, A., & Apte, R. S. (2018). Inflammation-induced photoreceptor cell death. In Advances in Experimental Medicine and Biology (pp. 203-208). (Advances in Experimental Medicine and Biology; Vol. 1074). Springer New York LLC. https://doi.org/10.1007/978-3-319-75402-4_25