The epidemiologic literature on sexually transmitted infections, clinical prostatitis, prostatic calculi, polymorphisms in immune response genes, and nonsteroidal antiinflammatory drug use as potential sources and modifiers of intraprostatic inflammation is reviewed in relation to prostate cancer. Particular emphasis is placed on study methodology and its influence on study findings. Although evidence from reviewed epidemiologic studies, together with laboratory and clinical studies, is suggestive of a role for prostatic inflammation in the etiology of prostate cancer, additional large, prospective studies are necessary to address methodological limitations of existing studies, and to investigate a broader range of potential sources of intraprostatic inflammation.

Original languageEnglish
Pages (from-to)242-249
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Issue number3
StatePublished - May 2007


  • Epidemiology
  • Immune response
  • Inflammation
  • Nonsteroidal antiinflammatory drugs
  • Prostate cancer
  • Prostatitis
  • Sexually transmitted infections


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