@article{e35317f2f4374b3ea2ba4d5c267f3621,
title = "Inflammation in prostate carcinogenesis",
abstract = "About 20% of all human cancers are caused by chronic infection or chronic inflammatory states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate and to the development of chronic inflammation and regenerative 'risk factor' lesions, referred to as proliferative inflammatory atrophy (PIA). By developing new experimental animal models coupled with classical epidemiological studies, genetic epidemiological studies and molecular pathological approaches, we should be able to determine whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease.",
author = "{De Marzo}, {Angelo M.} and Platz, {Elizabeth A.} and Siobhan Sutcliffe and Jianfeng Xu and Henrik Gr{\"o}nberg and Drake, {Charles G.} and Yasutomo Nakai and Isaacs, {William B.} and Nelson, {William G.}",
note = "Funding Information: The authors would like to thank Amelia K. Thomas for sketching the early concept designs for figure 2. Support was received from the Department of Defense Congressional Dir. Med.Research Program; The Public Health Services National Institutes of Health (NIH) and the National Cancer Institute, NIH and National Cancer Institute Specialized Programs of Research Excellencein Prostate Cancer, and philanthropicsup-port from the Donald and Susan Sturm Foundation, B. L. Schwartz and R. A. Barry. A.M.D. is a Helen and Peter Bing Scholar through The Patrick C. Walsh Prostate Cancer Research Fund.",
year = "2007",
month = apr,
doi = "10.1038/nrc2090",
language = "English",
volume = "7",
pages = "256--269",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
number = "4",
}