Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis

Ashwin Parihar, Ines Valenta, Salwa Mikhail, Alessio Imperiale, Thomas H. Schindler

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose of the Review: Cardiac involvement in systemic sarcoidosis or isolated cardiac sarcoidosis plays a pivotal role in the clinical manifestation and prognostication. Active-inflammatory cardiac sarcoidosis is associated with a regional impairment of coronary microvascular function that may confer further detrimental effects on myocardial function needing further characterization. Recent Findings: Clinical investigations with cardiac positron emission tomography/computed tomography in conjunction with 18F-fluorodeoxyglucose to determine myocardial inflammation and 13N-ammonia to quantify myocardial blood flow (MBF) in patients with known or suspected cardiac sarcoidosis outlined that sarcoidosis-induced myocardial inflammation was associated with adverse effects on corresponding regional coronary microvascular function. Notably, immune-suppressive treatment caused reductions in myocardial inflammation were paralleled by improvements of coronary microvascular dysfunction outlining direct adverse effect of inflammation on coronary arteriolar function. Summary: This review summarizes contributions of cardiac PET imaging in the identification and characterization of active-inflammatory cardiac sarcoidosis, its effect on coronary microvascular function, treatment responses, and prognostic implications.

Original languageEnglish
JournalCurrent Cardiology Reports
DOIs
StateAccepted/In press - 2024

Keywords

  • F-fluorodeoxyglucose
  • Cardiac involvement
  • Inflammation myocardial blood flow
  • Myocardial flow reserve
  • Positron emission tomography
  • Prognosis
  • Sarcoidosis

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