TY - JOUR
T1 - Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis
AU - Parihar, Ashwin Singh
AU - Valenta, Ines
AU - Mikhail, Salwa
AU - Imperiale, Alessio
AU - Schindler, Thomas H.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/7
Y1 - 2024/7
N2 - Purpose of the Review: Cardiac involvement in systemic sarcoidosis or isolated cardiac sarcoidosis plays a pivotal role in the clinical manifestation and prognostication. Active-inflammatory cardiac sarcoidosis is associated with a regional impairment of coronary microvascular function that may confer further detrimental effects on myocardial function needing further characterization. Recent Findings: Clinical investigations with cardiac positron emission tomography/computed tomography in conjunction with 18F-fluorodeoxyglucose to determine myocardial inflammation and 13N-ammonia to quantify myocardial blood flow (MBF) in patients with known or suspected cardiac sarcoidosis outlined that sarcoidosis-induced myocardial inflammation was associated with adverse effects on corresponding regional coronary microvascular function. Notably, immune-suppressive treatment caused reductions in myocardial inflammation were paralleled by improvements of coronary microvascular dysfunction outlining direct adverse effect of inflammation on coronary arteriolar function. Summary: This review summarizes contributions of cardiac PET imaging in the identification and characterization of active-inflammatory cardiac sarcoidosis, its effect on coronary microvascular function, treatment responses, and prognostic implications.
AB - Purpose of the Review: Cardiac involvement in systemic sarcoidosis or isolated cardiac sarcoidosis plays a pivotal role in the clinical manifestation and prognostication. Active-inflammatory cardiac sarcoidosis is associated with a regional impairment of coronary microvascular function that may confer further detrimental effects on myocardial function needing further characterization. Recent Findings: Clinical investigations with cardiac positron emission tomography/computed tomography in conjunction with 18F-fluorodeoxyglucose to determine myocardial inflammation and 13N-ammonia to quantify myocardial blood flow (MBF) in patients with known or suspected cardiac sarcoidosis outlined that sarcoidosis-induced myocardial inflammation was associated with adverse effects on corresponding regional coronary microvascular function. Notably, immune-suppressive treatment caused reductions in myocardial inflammation were paralleled by improvements of coronary microvascular dysfunction outlining direct adverse effect of inflammation on coronary arteriolar function. Summary: This review summarizes contributions of cardiac PET imaging in the identification and characterization of active-inflammatory cardiac sarcoidosis, its effect on coronary microvascular function, treatment responses, and prognostic implications.
KW - Cardiac involvement
KW - F-fluorodeoxyglucose
KW - Inflammation myocardial blood flow
KW - Myocardial flow reserve
KW - Positron emission tomography
KW - Prognosis
KW - Sarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=85193856079&partnerID=8YFLogxK
U2 - 10.1007/s11886-024-02070-1
DO - 10.1007/s11886-024-02070-1
M3 - Article
C2 - 38775909
AN - SCOPUS:85193856079
SN - 1523-3782
VL - 26
SP - 717
EP - 722
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 7
ER -