Abstract
Innate immune responses are the host's first line of defense against human immunodeficiency virus type 1 (HIV-1) infection, with pattern recognition receptors detecting viral specific pathogen-associated molecular patterns and initiating antiviral responses. In response to HIV-1 nucleic acids or proteins, some pattern recognition receptors have the ability to assemble a large multiprotein complex called the inflammasome, which triggers pro-inflammatory cytokine release and a form of lytic programmed cell death called pyroptosis. Here, we review our current understanding of the mechanism of the inflammasome in sensing HIV-1 infection. Furthermore, we discuss the contribution of inflammasome activation in HIV-1 pathogenesis as well as potential strategies of targeting inflammasome activation for the treatment of HIV-1 infection.
Original language | English |
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Pages (from-to) | 248-252 |
Number of pages | 5 |
Journal | Medicine (United States) |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1 2022 |
Keywords
- CARD8 protein
- HIV-1
- Inflammasomes
- Pyroptosis