Infectious diarrhea in developed and developing countries

Allen C. Cheng, Jay R. McDonald, Nathan M. Thielman

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations


Diarrhea from gastrointestinal infection remains a common problem. In industrialized countries, management is aimed at reducing morbidity and defining groups that may benefit from further investigation. Most infectious diarrhea is self-limiting and only requires supportive management. Viral agents are increasingly recognized as causative agents of epidemic and sporadic diarrhea. In developing countries, diarrhea is a major cause of mortality in children. Oral rehydration therapy, guided by a clinical assessment of the degree of dehydration, is cheap, simple, and effective and remains the mainstay of management of infant diarrhea. Controversies focus on the optimal formulation of oral rehydration solution. A vaccine against rotavirus has the potential to save millions of lives worldwide.

Original languageEnglish
Pages (from-to)757-773
Number of pages17
JournalJournal of Clinical Gastroenterology
Issue number9
StatePublished - Oct 1 2005


  • Community-acquired infection
  • Cross-infection
  • Diarrhea
  • Dysentery
  • Gastroenteritis
  • Infantile diarrhea


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