TY - JOUR
T1 - Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus
AU - Paddock, Christopher D.
AU - Folk, Scott M.
AU - Shore, G. Merrill
AU - Machado, Linda J.
AU - Huycke, Mark M.
AU - Slater, Leonard N.
AU - Liddell, Allison M.
AU - Buller, Richard S.
AU - Storch, Gregory A.
AU - Monson, Thomas P.
AU - Rimland, David
AU - Sumner, John W.
AU - Singleton, Joseph
AU - Bloch, Karen C.
AU - Tang, Yi Wei
AU - Standaert, Steven M.
AU - Childs, James E.
PY - 2001/11/1
Y1 - 2001/11/1
N2 - The clinical course and laboratory evaluation of 21 patients coinfected with human immunodeficiency virus (HIV) and Ehrlichia chaffeensis or Ehrlichia ewingii are reviewed and summarized, including 13 cases of ehrlichiosis caused by E. chaffeensis, 4 caused by E. ewingii, and 4 caused by either E. chaffeensis or E. ewingii. Twenty patients were male, and the median CD4+ T lymphocyte count was 137 cells/μL. Exposures to infecting ticks were linked to recreational pursuits, occupations, and peridomestic activities. For 8 patients, a diagnosis of ehrlichiosis was not considered until 4 days after presentation. Severe manifestations occurred more frequently among patients infected with E. chaffeensis than they did among patients infected with E. ewingii, and all 6 deaths were caused by E. chaffeensis. Ehrlichiosis may be a life-threatening illness in HIV-infected persons, and the influence of multiple factors, including recent changes in the epidemiology and medical management of HIV infection, may increase the frequency with which ehrlichioses occur in this patient cohort.
AB - The clinical course and laboratory evaluation of 21 patients coinfected with human immunodeficiency virus (HIV) and Ehrlichia chaffeensis or Ehrlichia ewingii are reviewed and summarized, including 13 cases of ehrlichiosis caused by E. chaffeensis, 4 caused by E. ewingii, and 4 caused by either E. chaffeensis or E. ewingii. Twenty patients were male, and the median CD4+ T lymphocyte count was 137 cells/μL. Exposures to infecting ticks were linked to recreational pursuits, occupations, and peridomestic activities. For 8 patients, a diagnosis of ehrlichiosis was not considered until 4 days after presentation. Severe manifestations occurred more frequently among patients infected with E. chaffeensis than they did among patients infected with E. ewingii, and all 6 deaths were caused by E. chaffeensis. Ehrlichiosis may be a life-threatening illness in HIV-infected persons, and the influence of multiple factors, including recent changes in the epidemiology and medical management of HIV infection, may increase the frequency with which ehrlichioses occur in this patient cohort.
UR - http://www.scopus.com/inward/record.url?scp=0035503613&partnerID=8YFLogxK
U2 - 10.1086/323981
DO - 10.1086/323981
M3 - Article
C2 - 11568857
AN - SCOPUS:0035503613
SN - 1058-4838
VL - 33
SP - 1586
EP - 1594
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 9
ER -