TY - JOUR
T1 - Infant vocalizing and phenotypic outcomes in autism
T2 - Evidence from the first 2 years
AU - IBIS Network
AU - Plate, Samantha
AU - Yankowitz, Lisa
AU - Resorla, Leslie
AU - Swanson, Meghan R.
AU - Meera, Shoba Sreenath
AU - Estes, Annette
AU - Marrus, Natasha
AU - Cola, Meredith
AU - Petrulla, Victoria
AU - Faggen, Aubrey
AU - Pandey, Juhi
AU - Paterson, Sarah
AU - Pruett, John R.
AU - Hazlett, Heather
AU - Dager, Stephen
AU - St. John, Tanya
AU - Botteron, Kelly
AU - Zwaigenbaum, Lonnie
AU - Piven, Joseph
AU - Schultz, Robert T.
AU - Parish-Morris, Julia
N1 - Funding Information:
This project was funded by Federal grants from the National Institute of Child Health and Human Development (“A Longitudinal MRI Study of Infants at Risk for Autism,” R01HD055741, PI: Piven; “Intellectual and Development Disabilities Research Center: Clinical Translational—Core B”, U54HD086984, MPIs: Robinson and Schultz; “Brain and Behavior Study of Autism from Infancy through School Age,” 5R01HD055741‐14, PI: Piven), the National Institute on Deafness and Other Communication Disorders (“Infant Vocalizations as Early Markers of Autism Spectrum Disorder”, 1R03DC017944, PI: Parish‐Morris), and the National Institute of Mental Health (“MRI Based Presymptomatic Prediction of ASD,” 1R01MH118362‐01, 3R01MH118362‐02S1, MPIs: Pruett & Piven). The Autism Science Foundation also provided predoctoral fellowship funding (“Analyzing baby talk to better understand brain development in autism,” ASF #19‐006, PI: Yankowitz). Additional support was provided by the Allerton Foundation, the McMorris Family Foundation, and the Simons Foundation.
Publisher Copyright:
© 2021 The Authors. Child Development © 2021 Society for Research in Child Development
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Infant vocalizations are early-emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)- and high (HR)-risk for ASD (HR-ASD = 23, female = 3; HR-Neg = 35, female = 13; LR = 32, female = 10; 80% White; collected from 2007 to 2017 near Philadelphia) were analyzed at 6, 12, and 24 months. At 12 months, HR-ASD infants produced fewer vocalizations than HR-Neg infants. From 6 to 24 months, HR-Neg infants demonstrated steeper vocalization growth compared to HR-ASD and LR infants. Finally, among HR infants, vocalizing at 12 months was associated with language, social phenotype, and diagnosis at age 2. Infant vocalizing is an objective behavioral marker that could facilitate earlier detection of ASD.
AB - Infant vocalizations are early-emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)- and high (HR)-risk for ASD (HR-ASD = 23, female = 3; HR-Neg = 35, female = 13; LR = 32, female = 10; 80% White; collected from 2007 to 2017 near Philadelphia) were analyzed at 6, 12, and 24 months. At 12 months, HR-ASD infants produced fewer vocalizations than HR-Neg infants. From 6 to 24 months, HR-Neg infants demonstrated steeper vocalization growth compared to HR-ASD and LR infants. Finally, among HR infants, vocalizing at 12 months was associated with language, social phenotype, and diagnosis at age 2. Infant vocalizing is an objective behavioral marker that could facilitate earlier detection of ASD.
UR - http://www.scopus.com/inward/record.url?scp=85118333934&partnerID=8YFLogxK
U2 - 10.1111/cdev.13697
DO - 10.1111/cdev.13697
M3 - Article
C2 - 34708871
AN - SCOPUS:85118333934
VL - 93
SP - 468
EP - 483
JO - Child Development
JF - Child Development
SN - 0009-3920
IS - 2
ER -