Induction therapy in lung transplantation

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Strategies for induction in lung transplant recipients typically mirror those used in other solid organ transplant recipients. Polyclonal (Atgam, RATG) and monoclonal (OKT3) T-cell depleting agents, IL-2 Receptor antagonists (basiliximab and daclizumab) have been used most commonly. In spite of evidence from ISHLT registry reports that induction reduces acute rejection and has a small benefit in freedom from bronchiolitis obliterans and long-term survival, other studies have been less convincing in terms of long-term benefit. Future iterations of induction strategy for lung transplant recipients will hopefully utilize tolerogenic approaches currently being tested in renal transplantation.

Original languageEnglish
Pages (from-to)696-703
Number of pages8
JournalTransplant International
Volume26
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • immunosuppression
  • induction
  • lung clinical
  • tolerance

Fingerprint

Dive into the research topics of 'Induction therapy in lung transplantation'. Together they form a unique fingerprint.

Cite this