Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli

Matthew A. Mulvey, Yolanda S. Lopez-Boado, Carole L. Wilson, Robyn Roth, William C. Parks, John Heuser, Scott J. Hultgren

Research output: Contribution to journalArticle

700 Scopus citations

Abstract

Virtually all uropathogenic strains of Escherichia coli encode filamentous surface adhesive organelles called type 1 pili. High-resolution electron microscopy of infected mouse bladders revealed that type 1 pilus tips interacted directly with the lumenal surface of the bladder, which is embedded with hexagonal arrays of integral membrane glycoproteins known as uroplakins. Attached pili were shortened and facilitated intimate contact of the bacteria with the uroplakin-coated host cells. Bacterial attachment resulted in exfoliation of host bladder epithelial cells as part of an innate host defense system. Exfoliation occurred through a rapid apoptosis-like mechanism involving caspase activation and host DNA fragmentation. Bacteria resisted clearance in the face of host defenses within the bladder by invading into the epithelium.

Original languageEnglish
Pages (from-to)1494-1497
Number of pages4
JournalScience
Volume282
Issue number5393
DOIs
StatePublished - Nov 20 1998

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    Mulvey, M. A., Lopez-Boado, Y. S., Wilson, C. L., Roth, R., Parks, W. C., Heuser, J., & Hultgren, S. J. (1998). Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science, 282(5393), 1494-1497. https://doi.org/10.1126/science.282.5393.1494