Inducing sleep by remote control facilitates memory consolidation in Drosophila

Jeffrey M. Donlea; Matthew S. Thimgan; Yasuko Suzuki; Laura Gottschalk; Paul J. Shaw

doi:10.1126/science.1202249

Inducing sleep by remote control facilitates memory consolidation in Drosophila

Jeffrey M. Donlea
, Matthew S. Thimgan
, Yasuko Suzuki
, Laura Gottschalk
, Paul J. Shaw

Research output: Contribution to journal › Article › peer-review

289 Scopus citations

Abstract

Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.

Original language	English
Pages (from-to)	1571-1576
Number of pages	6
Journal	Science
Volume	332
Issue number	6037
DOIs	https://doi.org/10.1126/science.1202249
State	Published - Jun 24 2011

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AU - Thimgan, Matthew S.

AU - Suzuki, Yasuko

AU - Gottschalk, Laura

AU - Shaw, Paul J.

PY - 2011/6/24

Y1 - 2011/6/24

N2 - Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.

AB - Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.

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ER -

Inducing sleep by remote control facilitates memory consolidation in Drosophila

Abstract

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