Induced Pluripotent Stem Cell-Derived Hepatocytes and Precision Medicine in Human Liver Disease

Research output: Contribution to journalArticle

Abstract

Liver-like human cells can be generated from human skin by converting fibroblasts to "induced pluripotent stem cells" (iPSCs), then differentiating the iPSCs into "induced hepatocytes". Although still primarily used as a research tool, emerging applications involving iPSC-derived induced hepatocytes have exciting and provocative clinical and translational potential. This review provides a brief summary of the current status of this field and obstacles that must be overcome before this novel tool will enable precision medicine-based approaches to human liver disease.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalJournal of pediatric gastroenterology and nutrition
Volume66
Issue number5
DOIs
StatePublished - May 1 2018

Keywords

  • drug development
  • hepatotoxicity
  • induced hepatocytes
  • induced pluripotent stem cell
  • liver disease
  • liver regeneration

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