Abstract
Liver-like human cells can be generated from human skin by converting fibroblasts to "induced pluripotent stem cells" (iPSCs), then differentiating the iPSCs into "induced hepatocytes". Although still primarily used as a research tool, emerging applications involving iPSC-derived induced hepatocytes have exciting and provocative clinical and translational potential. This review provides a brief summary of the current status of this field and obstacles that must be overcome before this novel tool will enable precision medicine-based approaches to human liver disease.
| Original language | English |
|---|---|
| Pages (from-to) | 716-719 |
| Number of pages | 4 |
| Journal | Journal of pediatric gastroenterology and nutrition |
| Volume | 66 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2018 |
Keywords
- drug development
- hepatotoxicity
- induced hepatocytes
- induced pluripotent stem cell
- liver disease
- liver regeneration