Topical administration of prostaglandin E2 to the eyes of rabbits elevated intraocular pressure. Topically applied arachidonic acid, a precursor of prostaglandin E2, also raised intraocular pressure. Pretreatment with intraperitoneal indomethacin completely prevented the elevation of intraocular pressure induced by topically applied arachidonic acid, but failed to block the rise of intraocular pressure caused by topical prostaglandin E2. The data suggested that indomethacin inhibited prostaglandin production from arachidonic acid in the eye.
|Number of pages||10|
|State||Published - Jan 1973|