Indomethacin blocks arachidonic acid-induced elevation of intraocular pressure

Steven M. Podos; Bernard Becker; Michael A. Kass

doi:10.1016/0090-6980(73)90133-0

Indomethacin blocks arachidonic acid-induced elevation of intraocular pressure

Steven M. Podos, Bernard Becker, Michael A. Kass

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Abstract

Topical administration of prostaglandin E₂ to the eyes of rabbits elevated intraocular pressure. Topically applied arachidonic acid, a precursor of prostaglandin E₂, also raised intraocular pressure. Pretreatment with intraperitoneal indomethacin completely prevented the elevation of intraocular pressure induced by topically applied arachidonic acid, but failed to block the rise of intraocular pressure caused by topical prostaglandin E₂. The data suggested that indomethacin inhibited prostaglandin production from arachidonic acid in the eye.

Original language	English
Pages (from-to)	7-16
Number of pages	10
Journal	Prostaglandins
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0090-6980(73)90133-0
State	Published - Jan 1973

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title = "Indomethacin blocks arachidonic acid-induced elevation of intraocular pressure",

abstract = "Topical administration of prostaglandin E2 to the eyes of rabbits elevated intraocular pressure. Topically applied arachidonic acid, a precursor of prostaglandin E2, also raised intraocular pressure. Pretreatment with intraperitoneal indomethacin completely prevented the elevation of intraocular pressure induced by topically applied arachidonic acid, but failed to block the rise of intraocular pressure caused by topical prostaglandin E2. The data suggested that indomethacin inhibited prostaglandin production from arachidonic acid in the eye.",

author = "Podos, {Steven M.} and Bernard Becker and Kass, {Michael A.}",

note = "Funding Information: This work was supported in part by a grant, EY-00004, and a special fellowship (Dr. Kass), 1 -FO-3-EY53981-01, from the U.S. Public Health Service. Dr. John E. Pike of the Upjohn Company kindly provided the prostaglandins.",

year = "1973",

month = jan,

doi = "10.1016/0090-6980(73)90133-0",

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T1 - Indomethacin blocks arachidonic acid-induced elevation of intraocular pressure

AU - Podos, Steven M.

AU - Becker, Bernard

AU - Kass, Michael A.

N1 - Funding Information: This work was supported in part by a grant, EY-00004, and a special fellowship (Dr. Kass), 1 -FO-3-EY53981-01, from the U.S. Public Health Service. Dr. John E. Pike of the Upjohn Company kindly provided the prostaglandins.

PY - 1973/1

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N2 - Topical administration of prostaglandin E2 to the eyes of rabbits elevated intraocular pressure. Topically applied arachidonic acid, a precursor of prostaglandin E2, also raised intraocular pressure. Pretreatment with intraperitoneal indomethacin completely prevented the elevation of intraocular pressure induced by topically applied arachidonic acid, but failed to block the rise of intraocular pressure caused by topical prostaglandin E2. The data suggested that indomethacin inhibited prostaglandin production from arachidonic acid in the eye.

AB - Topical administration of prostaglandin E2 to the eyes of rabbits elevated intraocular pressure. Topically applied arachidonic acid, a precursor of prostaglandin E2, also raised intraocular pressure. Pretreatment with intraperitoneal indomethacin completely prevented the elevation of intraocular pressure induced by topically applied arachidonic acid, but failed to block the rise of intraocular pressure caused by topical prostaglandin E2. The data suggested that indomethacin inhibited prostaglandin production from arachidonic acid in the eye.

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VL - 3

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JO - Prostaglandins

JF - Prostaglandins

IS - 1

ER -

Indomethacin blocks arachidonic acid-induced elevation of intraocular pressure

Abstract

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