TY - JOUR
T1 - Indications and limitations of liver transplantation for hepatocellular carcinoma
AU - Wudel, L. James
AU - Chapman, William C.
PY - 2003/1
Y1 - 2003/1
N2 - Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide, yet remains difficult to treat, with dismal overall long-term survival rates. Recent strategies using liver transplantation for carefully selected patients with stage I and II HCC and cirrhosis have shown promising results, with 5-year survival rates comparable to survival rates for transplantation patients without malignancy. Currently, however, limited resources and a severe organ shortage make liver transplantation an option for only a limited number of patients with HCC in the United States. Future studies must document the long-term success of this therapy and improve methods for disease control before and after transplantation.
AB - Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide, yet remains difficult to treat, with dismal overall long-term survival rates. Recent strategies using liver transplantation for carefully selected patients with stage I and II HCC and cirrhosis have shown promising results, with 5-year survival rates comparable to survival rates for transplantation patients without malignancy. Currently, however, limited resources and a severe organ shortage make liver transplantation an option for only a limited number of patients with HCC in the United States. Future studies must document the long-term success of this therapy and improve methods for disease control before and after transplantation.
UR - http://www.scopus.com/inward/record.url?scp=0037264945&partnerID=8YFLogxK
U2 - 10.1016/S1055-3207(02)00092-3
DO - 10.1016/S1055-3207(02)00092-3
M3 - Review article
C2 - 12735131
AN - SCOPUS:0037264945
SN - 1055-3207
VL - 12
SP - 77
EP - 90
JO - Surgical Oncology Clinics of North America
JF - Surgical Oncology Clinics of North America
IS - 1
ER -