TY - JOUR
T1 - Increased white matter glycolysis in humans with cerebral small vessel disease
AU - Brier, Matthew R.
AU - Blazey, Tyler
AU - Raichle, Marcus E.
AU - Morris, John
AU - Benzinger, Tammie L.S.
AU - Vlassenko, Andrei G.
AU - Snyder, Abraham
AU - Goyal, Manu
N1 - Funding Information:
We are grateful to our research participants and their families for their altruism. We appreciate VG Lab members for their efforts in participant recruitment and acquiring, processing and assembling the AMBR dataset. We also acknowledge the Neuroimaging Labs Research Center, Knight Alzheimer’s Disease Research Center, cyclotron and imaging staff for making this research possible. Funding for this research was provided by the National Institutes of Health/National Institute on Aging RF1AG073210 (A.G.V. and M.S.G.), R01AG057536 (A.G.V. and M.S.G.), R01AG053503 (A.G.V. and M.E.R.), P50AG005681 (J.C.M.), P01AG026276 (J.C.M.) and P01AG003991 (J.C.M. and T.L.S.B.). M.R.B. was supported by grants R25NS090978 and KL2TR002346 from NIH. Some of the MRI sequences were obtained from the Massachusetts General Hospital.
Funding Information:
T.L.S.B. and M.S.G. have received sponsored research grant support from Siemens Healthineers AG. The other authors declare no competing interests.
Funding Information:
We are grateful to our research participants and their families for their altruism. We appreciate VG Lab members for their efforts in participant recruitment and acquiring, processing and assembling the AMBR dataset19. We also acknowledge the Neuroimaging Labs Research Center, Knight Alzheimer’s Disease Research Center, cyclotron and imaging staff for making this research possible. Funding for this research was provided by the National Institutes of Health/National Institute on Aging RF1AG073210 (A.G.V. and M.S.G.), R01AG057536 (A.G.V. and M.S.G.), R01AG053503 (A.G.V. and M.E.R.), P50AG005681 (J.C.M.), P01AG026276 (J.C.M.) and P01AG003991 (J.C.M. and T.L.S.B.). M.R.B. was supported by grants R25NS090978 and KL2TR002346 from NIH. Some of the MRI sequences were obtained from the Massachusetts General Hospital.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/11
Y1 - 2022/11
N2 - White matter lesions in cerebral small vessel disease are related to ischemic injury and increase the risk of stroke and cognitive decline. Pathological changes due to cerebral small vessel disease are increasingly recognized outside of discrete lesions, but the metabolic alterations in nonlesional tissue has not been described. Aerobic glycolysis is critical to white matter myelin homeostasis and repair. In this study, we examined cerebral metabolism of glucose and oxygen as well as blood flow in individuals with and without cerebral small vessel disease using multitracer positron emission tomography. We show that glycolysis is relatively elevated in nonlesional white matter in individuals with small vessel disease relative to healthy, age-matched controls. On the other hand, in young healthy individuals, glycolysis is relatively low in areas of white matter susceptible to lesion formation. These results suggest that increased white matter glycolysis is a marker of pathology associated with small vessel disease.
AB - White matter lesions in cerebral small vessel disease are related to ischemic injury and increase the risk of stroke and cognitive decline. Pathological changes due to cerebral small vessel disease are increasingly recognized outside of discrete lesions, but the metabolic alterations in nonlesional tissue has not been described. Aerobic glycolysis is critical to white matter myelin homeostasis and repair. In this study, we examined cerebral metabolism of glucose and oxygen as well as blood flow in individuals with and without cerebral small vessel disease using multitracer positron emission tomography. We show that glycolysis is relatively elevated in nonlesional white matter in individuals with small vessel disease relative to healthy, age-matched controls. On the other hand, in young healthy individuals, glycolysis is relatively low in areas of white matter susceptible to lesion formation. These results suggest that increased white matter glycolysis is a marker of pathology associated with small vessel disease.
UR - http://www.scopus.com/inward/record.url?scp=85141652741&partnerID=8YFLogxK
U2 - 10.1038/s43587-022-00303-y
DO - 10.1038/s43587-022-00303-y
M3 - Article
C2 - 37118084
AN - SCOPUS:85141652741
SN - 2662-8465
VL - 2
SP - 991
EP - 999
JO - Nature Aging
JF - Nature Aging
IS - 11
ER -