Increased tumor necrosis factor α mRNA after cellular exposure to ionizing radiation

D. E. Hallahan, D. R. Spriggs, M. A. Beckett, D. W. Kufe, R. R. Weichselbaum

Research output: Contribution to journalArticle

372 Scopus citations

Abstract

We report that tumor necrosis factor α (TNF-α) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-α mRNA is accompanied by the increased production of TNF-α protein. TNF-α enhances radiation lethality in both TNF-α-producing and -nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-α may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-α and therapeutic radiation may be useful in clinical cancer therapy.

Original languageEnglish
Pages (from-to)10104-10107
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number24
DOIs
StatePublished - Dec 1 1989
Externally publishedYes

Keywords

  • Gene expression

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