Increased tumor necrosis factor α mRNA after cellular exposure to ionizing radiation

D. E. Hallahan; D. R. Spriggs; M. A. Beckett; D. W. Kufe; R. R. Weichselbaum

doi:10.1073/pnas.86.24.10104

Increased tumor necrosis factor α mRNA after cellular exposure to ionizing radiation

D. E. Hallahan, D. R. Spriggs, M. A. Beckett, D. W. Kufe, R. R. Weichselbaum

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Abstract

We report that tumor necrosis factor α (TNF-α) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-α mRNA is accompanied by the increased production of TNF-α protein. TNF-α enhances radiation lethality in both TNF-α-producing and -nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-α may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-α and therapeutic radiation may be useful in clinical cancer therapy.

Original language	English
Pages (from-to)	10104-10107
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	86
Issue number	24
DOIs	https://doi.org/10.1073/pnas.86.24.10104
State	Published - 1989

Keywords

Gene expression

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10.1073/pnas.86.24.10104

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title = "Increased tumor necrosis factor α mRNA after cellular exposure to ionizing radiation",

abstract = "We report that tumor necrosis factor α (TNF-α) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-α mRNA is accompanied by the increased production of TNF-α protein. TNF-α enhances radiation lethality in both TNF-α-producing and -nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-α may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-α and therapeutic radiation may be useful in clinical cancer therapy.",

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AU - Hallahan, D. E.

AU - Spriggs, D. R.

AU - Beckett, M. A.

AU - Kufe, D. W.

AU - Weichselbaum, R. R.

PY - 1989

Y1 - 1989

N2 - We report that tumor necrosis factor α (TNF-α) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-α mRNA is accompanied by the increased production of TNF-α protein. TNF-α enhances radiation lethality in both TNF-α-producing and -nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-α may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-α and therapeutic radiation may be useful in clinical cancer therapy.

AB - We report that tumor necrosis factor α (TNF-α) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-α mRNA is accompanied by the increased production of TNF-α protein. TNF-α enhances radiation lethality in both TNF-α-producing and -nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-α may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-α and therapeutic radiation may be useful in clinical cancer therapy.

KW - Gene expression

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

Increased tumor necrosis factor α mRNA after cellular exposure to ionizing radiation

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Keywords

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