Increased tissue nitric oxide (NO) and cortical blood flow during functional activation of rat brain

Donald G. Buerk, Beau M. Ances, John A. Detre, Joel H. Greenberg

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Tissue nitric oxide (NO) was measured in rat somatosensory cortex using NO-sensitive electrochemical microsensors during functional activation of the brain by electrical stimulation of the forepaw, while simultaneously measuring cortical blood flow by laser Doppler flowmetry. Measurements show a rapid increase in NO which precedes the rise in cortical blood flow, suggesting that NO plays an important role in coupling cerebral blood flow with neuronal activity.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

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