Increased systemic inflammation overnight correlates with insulin resistance among children evaluated for obstructive sleep apnea

Mark D. DeBoer, James P. Mendoza, Lei Liu, Gabriele Ford, Pearl L. Yu, Benjamin M. Gaston

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Purpose: Obstructive sleep apnea (OSA) in children is associated with obesity, insulin resistance, and elevated baseline inflammation as measured by high-sensitivity C-reactive protein (hsCRP). Our goal was to evaluate whether inflammation increases overnight among children suspected of having OSA and to determine whether worsened inflammation is associated with the degree of OSA severity, obesity, and/or insulin resistance. Methods: Twenty-three children with clinical suspicion of OSA underwent a sleep study. Levels of hsCRP were tested the evening before and morning after the sleep study. Fasting insulin and glucose levels were measured from which the homeostasis model of insulin resistance (HOMA-IR) was calculated. Linear correlations were performed to evaluate relationships between hsCRP levels at baseline and change overnight (ΔhsCRP) vs. HOMA-IR, body mass index (BMI) z-score, and sleep study parameters related to O 2 saturation and the apneahypopnea index (AHI). Results: Among children with OSA and the entire cohort, hsCRP values were correlated with HOMA-IR and BMI z-scores. HOMA-IR but not BMI z-score correlated with ΔhsCRP overnight in the entire cohort. Sleep study parameters, including AHI mean O 2 saturation overnight, REM O 2 nadir, and non-REM O 2 nadir were not correlated with hsCRP or ΔhsCRP overnight. Conclusion: Among children being evaluated for OSA, degree of insulin resistance may be an important determinant of increased systemic inflammation overnight. Sleep study markers did not correlate with ΔhsCRP, leaving uncertain the role of OSA in increasing inflammation overnight. Further studies are needed to explore these associations and their potential mechanisms.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalSleep and Breathing
Issue number2
StatePublished - Jun 2012


  • Adolescents
  • Inflammation hscrp
  • Insulin resistance
  • Obesity
  • Obstructive sleep apnea
  • Oxygen desaturation


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