Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice

Ebru Erbayat-Altay, Kelvin A. Yamada, Michael Wong, Liu Lin Thio

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Leptin modulates multiple ion channels making its net effect on brain excitability difficult to predict. One method of determining leptin's net effect on brain excitability is to examine brain excitability during chronic leptin deficiency. We compared the susceptibility of leptin deficient ob/ob and wild type mice to pentylenetetrazol (PTZ) induced seizures using continuous video electroencephalogram (EEG) recordings. We found that ob/ob mice were more likely to die and were more susceptible to generalized clonic and clonic-tonic seizures than wild type mice at submaximal PTZ doses. These findings suggest that chronic leptin deficiency in vivo increases seizure susceptibility.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalNeuroscience Letters
Volume433
Issue number2
DOIs
StatePublished - Mar 12 2008

Keywords

  • Absence seizure
  • Anticonvulsant
  • Clonic-tonic seizure
  • Ketogenic diet
  • Myoclonic seizure
  • Video EEG

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