TY - JOUR
T1 - Increased serum soluble interleukin-2 receptors in caucasian and Korean schizophrenic patients
AU - Rapaport, Mark Hyman
AU - McAllister, Cathy G.
AU - Yong Sik Kim, Sik Kim
AU - Jin Hee Han, Hee Han
AU - Pickar, David
AU - Nelson, David L.
AU - Kirch, Darrell G.
AU - Paul, Steven M.
PY - 1994/5/15
Y1 - 1994/5/15
N2 - Recent studies have identified immunologic abnormalities in some schizophrenic subjects. This experiment replicates previous findings that serum soluble interleukin-2 receptors (SIL-2Rs) are elevated in schizophrenic patients, and is the first study to describe this phenomenon in non-Caucasian patients. Despite differences between Korean and Caucasian schizophrenic patients in absolute serum SIL-2R levels, both groups were significantly elevated when compared with their respective ethnic control groups (477 ± 171 U/ml versus 354 ± 172 U/ml and 763±347 U/ml versus 567±231 U/ml, respectively). Neither age, gender, medication status, nor duration of illness correlated with SIL-2R levels. These findings are further evidence that immune activation is present, regardless of ethnic origin, in some schizophrenic patients.
AB - Recent studies have identified immunologic abnormalities in some schizophrenic subjects. This experiment replicates previous findings that serum soluble interleukin-2 receptors (SIL-2Rs) are elevated in schizophrenic patients, and is the first study to describe this phenomenon in non-Caucasian patients. Despite differences between Korean and Caucasian schizophrenic patients in absolute serum SIL-2R levels, both groups were significantly elevated when compared with their respective ethnic control groups (477 ± 171 U/ml versus 354 ± 172 U/ml and 763±347 U/ml versus 567±231 U/ml, respectively). Neither age, gender, medication status, nor duration of illness correlated with SIL-2R levels. These findings are further evidence that immune activation is present, regardless of ethnic origin, in some schizophrenic patients.
KW - SIL-2Rs
KW - Schizophrenia
KW - biological psychiatry
KW - ethnicity
KW - immunology
KW - psychotropic medication
UR - https://www.scopus.com/pages/publications/0028176976
U2 - 10.1016/0006-3223(94)91137-1
DO - 10.1016/0006-3223(94)91137-1
M3 - Article
C2 - 8043705
AN - SCOPUS:0028176976
SN - 0006-3223
VL - 35
SP - 767
EP - 771
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 10
ER -