Increased serum soluble interleukin-2 receptors in caucasian and Korean schizophrenic patients

Mark Hyman Rapaport, Cathy G. McAllister, Sik Kim Yong Sik Kim, Hee Han Jin Hee Han, David Pickar, David L. Nelson, Darrell G. Kirch, Steven M. Paul

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58 Scopus citations


Recent studies have identified immunologic abnormalities in some schizophrenic subjects. This experiment replicates previous findings that serum soluble interleukin-2 receptors (SIL-2Rs) are elevated in schizophrenic patients, and is the first study to describe this phenomenon in non-Caucasian patients. Despite differences between Korean and Caucasian schizophrenic patients in absolute serum SIL-2R levels, both groups were significantly elevated when compared with their respective ethnic control groups (477 ± 171 U/ml versus 354 ± 172 U/ml and 763±347 U/ml versus 567±231 U/ml, respectively). Neither age, gender, medication status, nor duration of illness correlated with SIL-2R levels. These findings are further evidence that immune activation is present, regardless of ethnic origin, in some schizophrenic patients.

Original languageEnglish
Pages (from-to)767-771
Number of pages5
JournalBiological Psychiatry
Issue number10
StatePublished - May 15 1994


  • SIL-2Rs
  • Schizophrenia
  • biological psychiatry
  • ethnicity
  • immunology
  • psychotropic medication


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