Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance

S. D. Edland, J. M. Silverman, E. R. Peskind, D. Tsuang, E. Wijsman, J. C. Morris

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

This study tests the hypothesis of maternal inheritance of AD in families of 118 subjects with this disorder enrolled in The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). The parental generation included 24 subjects with dementia. Using the Cox proportional hazards model, we found the age-adjusted mother-to-father relative risk to be 2.8 (95% CI, 1.1 to 7.7). Among a subset of 10 families with one affected parent and at least two affected siblings, the ratio of affected mothers-to-fathers was 9:1. These findings support recent studies that found a high mother-to- father ratio among affected parents of subjects with AD. Together, these results suggest maternal inheritance of AD and are consistent with several hypotheses regarding the genetic nature of AD.

Original languageEnglish
Pages (from-to)254-256
Number of pages3
JournalNeurology
Volume47
Issue number1
DOIs
StatePublished - Jul 1996

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