Increased oxidative stress in kwashiorkor

Mark J. Manary, Christiaan Leeuwenburgh, Jay W. Heinecke

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


To test the hypothesis that kwashiorkor is associated with increased oxidative stress, urinary concentrations of 2 oxidized amino acids, o,o'-dityrosine and ortho-tyrosine, were measured by gas chromatography-mass spectrometry. Children with kwashiorkor, with or without infection, had a 3- to 7-fold increase in urinary o,o'-dityrosine and a 1.5- to 2-fold increase in ortho-tyrosine when compared with well-nourished children. This observation raises the possibility that oxidative damage to proteins and other biologic targets plays a role in the clinical manifestations of kwashiorkor.

Original languageEnglish
Pages (from-to)421-424
Number of pages4
JournalJournal of Pediatrics
Issue number3
StatePublished - 2000


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