TY - JOUR
T1 - Increased Numbers of CD5 B Lymphocytes in Schizophrenic Patients
AU - Mcallister, Cathy G.
AU - Rapaport, Mark Hyman
AU - Pickar, David
AU - Podruchny, Teresa A.
AU - Christison, George
AU - Alphs, Larry D.
AU - Paul, Steven M.
PY - 1989/10
Y1 - 1989/10
N2 - Autoimmune mechanisms have been postulated to play a role in the pathogenesis of schizophrenia. Recently, increased numbers of B lymphocytes expressing the CD5 (Leu-1) surface antigen have been observed in patients with certain autoimmune diseases. In the present study, approximately 30% of schizophrenic patients (11/34) were found by cytofluorometric methods to have similarly increased levels of circulating CD5 B cells compared with 6% (2/33) of healthy individuals and 5% (1/20) of patients with bipolar affective disorder. In schizophrenic patients with a “high” CD5 B-cell phenotype, the percentage of B cells expressing the CD5 surface marker (mean + SEM, 52.4% + 3.5%) was comparable to that reported for patients with rheumatoid arthritis and significantly greater than that reported for patients with bipolar affective disorder (25.7%±2.5%) and healthy controls (31.0% ±1.8%). Schizophrenic patients with high levels of CD5 B cells had increased numbers of total B cells compared with control subjects and patients with low levels of CD5 B cells. An elevation in CD5+ B cells may delineate a subgroup of schizophrenic patients whose disease has an underlying autoimmune and/or genetic cause.
AB - Autoimmune mechanisms have been postulated to play a role in the pathogenesis of schizophrenia. Recently, increased numbers of B lymphocytes expressing the CD5 (Leu-1) surface antigen have been observed in patients with certain autoimmune diseases. In the present study, approximately 30% of schizophrenic patients (11/34) were found by cytofluorometric methods to have similarly increased levels of circulating CD5 B cells compared with 6% (2/33) of healthy individuals and 5% (1/20) of patients with bipolar affective disorder. In schizophrenic patients with a “high” CD5 B-cell phenotype, the percentage of B cells expressing the CD5 surface marker (mean + SEM, 52.4% + 3.5%) was comparable to that reported for patients with rheumatoid arthritis and significantly greater than that reported for patients with bipolar affective disorder (25.7%±2.5%) and healthy controls (31.0% ±1.8%). Schizophrenic patients with high levels of CD5 B cells had increased numbers of total B cells compared with control subjects and patients with low levels of CD5 B cells. An elevation in CD5+ B cells may delineate a subgroup of schizophrenic patients whose disease has an underlying autoimmune and/or genetic cause.
UR - http://www.scopus.com/inward/record.url?scp=0024441542&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1989.01810100032006
DO - 10.1001/archpsyc.1989.01810100032006
M3 - Article
C2 - 2478093
AN - SCOPUS:0024441542
SN - 0003-990X
VL - 46
SP - 890
EP - 894
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 10
ER -