Increased number of hypothalamic [3H](+)-amphetamine binding sites in genetically obese (ob/ob) mice

R. Hauger, B. Hulihan-Glblin, S. M. Paul

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In genetically obese (ob/ob) mice the development of obesity was correlated with the binding of [3H](+)-amphetamine to the hypothalamus. In 39-day-old ob/ob mice, which had obtained a body weight > 150% of their lean littermates, hypothalamic [3H](+)-amphetamine binding had increased by approximately 60% above levels of their lean littermates. This increased number of hypothalamic [3H](+)-amphetamine binding sites appeared during the onset of obesity and then remained elevated following the most prominent weight gain. Since ob/ob mice are markedly hyperglycemic throughout their life, the increase in [3H](+)-amphetamine binding site density in the hypothalamus may be secondary to elevated blood glucose.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
Issue number3
StatePublished - Mar 1986


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