Increased frequency of Tim-3 expressing T cells is associated with symptomatic West Nile virus infection

Marion C. Lanteri, Michael S. Diamond, Jacqueline P. Law, Glen M. Chew, Shiquan Wu, Heather C. Inglis, Derek Wong, Michael P. Busch, Philip J. Norris, Lishomwa C. Ndhlovu

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12 Scopus citations

Abstract

More than a decade after West Nile virus (WNV) entered North America, and despite a significant increase in reported cases during the 2012 and 2013 seasons, no treatment or vaccine for humans is available. Although antiviral T cells contribute to the control of WNV, little is known about their regulation during acute infection. We analyzed the expression of Tim-3 and PD-1, two recently identified T cell negative immune checkpoint receptors, over the course of WNV infection. Symptomatic WNV+ donors exhibited higher frequencies of Tim-3+ cells than asymptomatic subjects within naïve/early differentiated CD28+/-CD57-CD4 + and differentiated CD28-CD57-CD8+ T cells. Our study links Tim-3-expression on T cells during acute WNV infection with the development of symptomatic disease, suggesting Tim-3 and its ligands could be targeted therapeutically to alter anti-WNV immunity and improve disease outcome.

Original languageEnglish
Article numbere92134
JournalPloS one
Volume9
Issue number3
DOIs
StatePublished - Mar 18 2014

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