Increased Cortical Cerebral Blood Flow in Asymptomatic Human Immunodeficiency Virus-Infected Subjects

Souvik Sen, Hongyu An, Prema Menezes, Jonathan Oakes, Joseph Eron, Weili Lin, Kevin Robertson, William Powers

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background Human immunodeficiency virus (HIV)-infected individuals are at high risk for ischemic stroke. To investigate the physiological basis for this risk, we used magnetic resonance imaging (MRI) to measure oxygen extraction fraction (OEF) and cerebral blood flow (CBF) in treatment-naive asymptomatic HIV-infected subjects and controls. Methods In treatment-naive asymptomatic HIV-infected subjects and age-, gender-, and race-matched controls, OEF was measured by MRI asymmetric spin–echo echo-planar imaging sequences and CBF was measured by MRI pseudocontinuous arterial spin labeling. Results Twenty-six treatment-naive HIV-infected subjects and 27 age-, gender-, race-matched controls participated. Whole-brain, gray matter (GM), and white matter OEF were not different between the groups (all P > .70). Unexpectedly, HIV-infected subjects had significantly higher CBF in cortical GM (72.9 ± 16.2 mL/100 g/min versus 63.9 ± 9.9 mL/100 g/min; P = .01) but not in subcortical GM (P = .25). Conclusions The observed increase in cortical GM CBF in treatment-naive HIV-infected subjects is unexpected, contrary to CBF decreases reported in HIV-infected subjects on treatment, and may represent an initial increase in metabolic activity due to an HIV-mediated inflammation.

Original languageEnglish
Pages (from-to)1891-1895
Number of pages5
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number8
StatePublished - Aug 1 2016


  • Cerebral blood flow measurement
  • MRI
  • cerebrovascular disease
  • infectious disease
  • inflammation


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