Incorporating Breast Anatomy in Computational Phenotyping of Mammographic Parenchymal Patterns for Breast Cancer Risk Estimation

Aimilia Gastounioti, Meng Kang Hsieh, Eric Cohen, Lauren Pantalone, Emily F. Conant, Despina Kontos

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We retrospectively analyzed negative screening digital mammograms from 115 women who developed unilateral breast cancer at least one year later and 460 matched controls. Texture features were estimated in multiple breast regions defined by an anatomically-oriented polar grid, and were weighted by their position and underlying dense versus fatty tissue composition. Elastic net regression with cross-validation was performed and area under the curve (AUC) of the receiver operating characteristic (ROC) was used to evaluate ability to predict breast cancer. We also compared our anatomy-augmented features to current state-of-the-art in which parenchymal texture was assessed without considering breast anatomy and evaluated the added value of the extracted features to breast density, body-mass-index (BMI) and age as baseline predictors. Our anatomy-augmented texture features resulted in higher discriminatory capacity (AUC = 0.63 vs. AUC = 0.59) when breast anatomy was not considered (p = 0.021), with dense tissue regions and the central breast quadrant being more heavily weighted. Texture also improved baseline models (from AUC = 0.62 to AUC = 0.67, p = 0.029). Our findings suggest that incorporating breast anatomy information could augment imaging markers of breast cancer risk with the potential to improve personalized breast cancer risk assessment.

Original languageEnglish
Article number17489
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

Dive into the research topics of 'Incorporating Breast Anatomy in Computational Phenotyping of Mammographic Parenchymal Patterns for Breast Cancer Risk Estimation'. Together they form a unique fingerprint.

Cite this