Incidentally Detected Chronic Lymphocytic Leukemia in Hilar Lymph Nodes at the Time of Lung Transplantation: A Case Report

Yuriko Terada; M. Shea Harrison; Ruben G. Nava; Chad A. Witt; Derek E. Byers; Rodrigo Vazquez Guillamet; Bryan F. Meyers; Michael K. Pasque; G. Alexander Patterson; Daniel Kreisel; Varun Puri; Ramsey R. Hachem; Tsuyoshi Takahashi

doi:10.1016/j.transproceed.2021.06.013

Incidentally Detected Chronic Lymphocytic Leukemia in Hilar Lymph Nodes at the Time of Lung Transplantation: A Case Report

Yuriko Terada, M. Shea Harrison, Ruben G. Nava, Chad A. Witt, Derek E. Byers, Rodrigo Vazquez Guillamet, Bryan F. Meyers, Michael K. Pasque, G. Alexander Patterson, Daniel Kreisel, Varun Puri, Ramsey R. Hachem, Tsuyoshi Takahashi

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Abstract

A 68-year-old man with interstitial pulmonary fibrosis underwent bilateral lung transplantation. Histopathologic examination of hilar lymph nodes in the explanted lungs showed effacement of normal nodal architecture by the proliferation of small lymphocytes, consistent with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). Unexpectedly discovered malignancies at the time of lung transplantation is uncommon, especially in the lymph nodes. The clinical management was challenging because of attempts to balance treatment of CLL and immunosuppressive treatment to prevent graft rejection. Here, we report a case of incidentally detected CLL in hilar lymph nodes with explanted lungs and review the relevant literature.

Original language	English
Pages (from-to)	2619-2621
Number of pages	3
Journal	Transplantation Proceedings
Volume	53
Issue number	8
DOIs	https://doi.org/10.1016/j.transproceed.2021.06.013
State	Published - Oct 2021

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Terada, Y., Harrison, M. S., Nava, R. G., Witt, C. A., Byers, D. E., Guillamet, R. V., Meyers, B. F., Pasque, M. K., Patterson, G. A., Kreisel, D., Puri, V., Hachem, R. R., & Takahashi, T. (2021). Incidentally Detected Chronic Lymphocytic Leukemia in Hilar Lymph Nodes at the Time of Lung Transplantation: A Case Report. Transplantation Proceedings, 53(8), 2619-2621. https://doi.org/10.1016/j.transproceed.2021.06.013

@article{c043b2fb87d0463fa01f9f467ba516e0,

title = "Incidentally Detected Chronic Lymphocytic Leukemia in Hilar Lymph Nodes at the Time of Lung Transplantation: A Case Report",

abstract = "A 68-year-old man with interstitial pulmonary fibrosis underwent bilateral lung transplantation. Histopathologic examination of hilar lymph nodes in the explanted lungs showed effacement of normal nodal architecture by the proliferation of small lymphocytes, consistent with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). Unexpectedly discovered malignancies at the time of lung transplantation is uncommon, especially in the lymph nodes. The clinical management was challenging because of attempts to balance treatment of CLL and immunosuppressive treatment to prevent graft rejection. Here, we report a case of incidentally detected CLL in hilar lymph nodes with explanted lungs and review the relevant literature.",

author = "Yuriko Terada and Harrison, {M. Shea} and Nava, {Ruben G.} and Witt, {Chad A.} and Byers, {Derek E.} and Guillamet, {Rodrigo Vazquez} and Meyers, {Bryan F.} and Pasque, {Michael K.} and Patterson, {G. Alexander} and Daniel Kreisel and Varun Puri and Hachem, {Ramsey R.} and Tsuyoshi Takahashi",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = oct,

doi = "10.1016/j.transproceed.2021.06.013",

language = "English",

volume = "53",

pages = "2619--2621",

journal = "Transplantation Proceedings",

issn = "0041-1345",

number = "8",

}

Terada, Y, Harrison, MS, Nava, RG , Witt, CA , Byers, DE , Guillamet, RV , Meyers, BF , Pasque, MK , Patterson, GA , Kreisel, D , Puri, V, Hachem, RR & Takahashi, T 2021, 'Incidentally Detected Chronic Lymphocytic Leukemia in Hilar Lymph Nodes at the Time of Lung Transplantation: A Case Report', Transplantation Proceedings, vol. 53, no. 8, pp. 2619-2621. https://doi.org/10.1016/j.transproceed.2021.06.013

TY - JOUR

T1 - Incidentally Detected Chronic Lymphocytic Leukemia in Hilar Lymph Nodes at the Time of Lung Transplantation

T2 - A Case Report

AU - Terada, Yuriko

AU - Harrison, M. Shea

AU - Nava, Ruben G.

AU - Witt, Chad A.

AU - Byers, Derek E.

AU - Guillamet, Rodrigo Vazquez

AU - Meyers, Bryan F.

AU - Pasque, Michael K.

AU - Patterson, G. Alexander

AU - Kreisel, Daniel

AU - Puri, Varun

AU - Hachem, Ramsey R.

AU - Takahashi, Tsuyoshi

PY - 2021/10

Y1 - 2021/10

N2 - A 68-year-old man with interstitial pulmonary fibrosis underwent bilateral lung transplantation. Histopathologic examination of hilar lymph nodes in the explanted lungs showed effacement of normal nodal architecture by the proliferation of small lymphocytes, consistent with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). Unexpectedly discovered malignancies at the time of lung transplantation is uncommon, especially in the lymph nodes. The clinical management was challenging because of attempts to balance treatment of CLL and immunosuppressive treatment to prevent graft rejection. Here, we report a case of incidentally detected CLL in hilar lymph nodes with explanted lungs and review the relevant literature.

AB - A 68-year-old man with interstitial pulmonary fibrosis underwent bilateral lung transplantation. Histopathologic examination of hilar lymph nodes in the explanted lungs showed effacement of normal nodal architecture by the proliferation of small lymphocytes, consistent with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). Unexpectedly discovered malignancies at the time of lung transplantation is uncommon, especially in the lymph nodes. The clinical management was challenging because of attempts to balance treatment of CLL and immunosuppressive treatment to prevent graft rejection. Here, we report a case of incidentally detected CLL in hilar lymph nodes with explanted lungs and review the relevant literature.

UR - http://www.scopus.com/inward/record.url?scp=85110439304&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2021.06.013

DO - 10.1016/j.transproceed.2021.06.013

M3 - Article

C2 - 34253378

AN - SCOPUS:85110439304

SN - 0041-1345

VL - 53

SP - 2619

EP - 2621

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 8

ER -

Incidentally Detected Chronic Lymphocytic Leukemia in Hilar Lymph Nodes at the Time of Lung Transplantation: A Case Report

Abstract

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