TY - JOUR
T1 - Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program
AU - of program collaborators for Environmental influences on Child Health Outcomes
AU - Miller, Rachel L.
AU - Schuh, Holly
AU - Chandran, Aruna
AU - Aris, Izzuddin M.
AU - Bendixsen, Casper
AU - Blossom, Jeffrey
AU - Breton, Carrie
AU - Camargo, Carlos A.
AU - Canino, Glorisa
AU - Carroll, Kecia N.
AU - Commodore, Sarah
AU - Cordero, José F.
AU - Dabelea, Dana M.
AU - Ferrara, Assiamira
AU - Fry, Rebecca C.
AU - Ganiban, Jody M.
AU - Gern, James E.
AU - Gilliland, Frank D.
AU - Gold, Diane R.
AU - Habre, Rima
AU - Hare, Marion E.
AU - Harte, Robyn N.
AU - Hartert, Tina
AU - Hasegawa, Kohei
AU - Khurana Hershey, Gurjit K.
AU - Jackson, Daniel J.
AU - Joseph, Christine
AU - Kerver, Jean M.
AU - Kim, Haejin
AU - Litonjua, Augusto A.
AU - Marsit, Carmen J.
AU - McEvoy, Cindy
AU - Mendonça, Eneida A.
AU - Moore, Paul E.
AU - Nkoy, Flory L.
AU - O'Connor, Thomas G.
AU - Oken, Emily
AU - Ownby, Dennis
AU - Perzanowski, Matthew
AU - Rivera-Spoljaric, Katherine
AU - Ryan, Patrick H.
AU - Singh, Anne Marie
AU - Stanford, Joseph B.
AU - Wright, Rosalind J.
AU - Wright, Robert O.
AU - Zanobetti, Antonella
AU - Zoratti, Edward
AU - Johnson, Christine C.
AU - Smith, P. B.
AU - Newby, K. L.
AU - Jacobson, L. P.
AU - Catellier, D. J.
AU - Gershon, R.
AU - Cella, D.
AU - Alshawabkeh, A.
AU - Aschner, J.
AU - Merhar, S.
AU - Ren, C.
AU - Reynolds, A.
AU - Keller, R.
AU - Pryhuber, G.
AU - Duncan, A.
AU - Lampland, A.
AU - Wadhawan, R.
AU - Wagner, C.
AU - Hudak, M.
AU - Mayock, D.
AU - Walshburn, L.
AU - Teitelbaum, S. L.
AU - Stroustrup, A.
AU - Trasande, L.
AU - Blair, C.
AU - Gatzke-Kopp, L.
AU - Swingler, M.
AU - Mansbach, J.
AU - Spergel, J.
AU - Puls, H.
AU - Stevenson, M.
AU - Bauer, C.
AU - Deoni, S.
AU - Duarte, C.
AU - Dunlop, A.
AU - Elliott, A.
AU - Croen, L.
AU - Bacharier, L.
AU - O'Connor, G.
AU - Kattan, M.
AU - Wood, R.
AU - Hershey, G.
AU - Ownby, D.
AU - Hertz-Picciotto, I.
AU - Hipwell, A.
AU - Karagas, M.
AU - Karr, C.
AU - Mason, A.
AU - Sathyanarayana, S.
AU - Lester, B.
AU - Carter, B.
AU - Neal, C.
AU - Smith, L.
AU - Helderman, J.
AU - Leve, L.
AU - Ganiban, J.
AU - Neiderhiser, J.
AU - Weiss, S.
AU - Zeiger, R.
AU - Tepper, R.
AU - Lyall, K.
AU - Landa, R.
AU - Ozonoff, S.
AU - Schmidt, R.
AU - Dager, S.
AU - Schultz, R.
AU - Piven, J.
AU - Volk, H.
AU - Vaidya, R.
AU - Obeid, R.
AU - Rollins, C.
AU - Bear, K.
AU - Pastyrnak, S.
AU - Lenski, M.
AU - Msall, M.
AU - Frazier, J.
AU - Washburn, L.
AU - Montgomery, A.
AU - Barone, C.
AU - McKane, P.
AU - Paneth, N.
AU - Elliott, M.
AU - Herbstman, J.
AU - Schantz, S.
AU - Porucznik, C.
AU - Silver, R.
AU - Conradt, E.
AU - Bosquet-Enlow, M.
AU - Huddleston, K.
AU - Bush, N.
AU - Nguyen, R.
AU - O'Connor, T.
AU - Samuels-Kalow, M.
N1 - Publisher Copyright:
© 2023 American Academy of Allergy, Asthma & Immunology
PY - 2023/7
Y1 - 2023/7
N2 - Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2- to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents.
AB - Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2- to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents.
KW - Asthma
KW - environmental and social determinants of asthma
KW - incidence rates
KW - recurrent exacerbations
UR - http://www.scopus.com/inward/record.url?scp=85156117743&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2023.03.016
DO - 10.1016/j.jaci.2023.03.016
M3 - Article
C2 - 36972767
AN - SCOPUS:85156117743
SN - 0091-6749
VL - 152
SP - 84
EP - 93
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1
ER -