Incidence of Occult Lymph Node Metastases in Pathological Stage C (pT3NO) Prostate Cancer

John A. Freeman, David Esrig, Gary D. Grossfeld, John P. Stein, Chen Su-Chiu, Lillian L. Young, Clive R. Taylor, Donald G. Skinner, Gary Lieskovsky, Richard J. Cote

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45 Scopus citations


Purpose: To determine the incidence of occult lymph node metastases in patients with stage pT3NO prostate cancer. Materials and Methods: Lymph nodes from 95 patients with stage pT3NO prostate cancer were analyzed by immunohistochemistry for extrinsic epithelial cells using epithelial-specific monoclonal antibodies. The extrinsic epithelial cells were also tested for prostate specific antigen expression. Results: Occult lymph node metastases were identified in 15 cases (16 percent) and were more frequent in patients with high primary Gleason grade tumors and seminal vesicle invasion (p = 0.03). In all cases the extrinsic cells were of prostate origin based on prostate specific antigen expression. Conclusions: Occult lymph node metastases can be detected in a substantial proportion of patients with stage pT3NO prostate cancer, are associated with known predictors of disease progression, and may be useful in identifying patients at risk for recurrence and progression.

Original languageEnglish
Pages (from-to)474-478
Number of pages5
JournalThe Journal of urology
Issue number2
StatePublished - Aug 1995


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