Incidence of Occult Lymph Node Metastases in Pathological Stage C (pT3NO) Prostate Cancer

John A. Freeman; David Esrig; Gary D. Grossfeld; John P. Stein; Chen Su-Chiu; Lillian L. Young; Clive R. Taylor; Donald G. Skinner; Gary Lieskovsky; Richard J. Cote

doi:10.1016/S0022-5347(01)67077-0

Incidence of Occult Lymph Node Metastases in Pathological Stage C (pT3NO) Prostate Cancer

John A. Freeman, David Esrig, Gary D. Grossfeld, John P. Stein, Chen Su-Chiu, Lillian L. Young, Clive R. Taylor, Donald G. Skinner, Gary Lieskovsky, Richard J. Cote

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Abstract

Purpose: To determine the incidence of occult lymph node metastases in patients with stage pT3NO prostate cancer. Materials and Methods: Lymph nodes from 95 patients with stage pT3NO prostate cancer were analyzed by immunohistochemistry for extrinsic epithelial cells using epithelial-specific monoclonal antibodies. The extrinsic epithelial cells were also tested for prostate specific antigen expression. Results: Occult lymph node metastases were identified in 15 cases (16 percent) and were more frequent in patients with high primary Gleason grade tumors and seminal vesicle invasion (p = 0.03). In all cases the extrinsic cells were of prostate origin based on prostate specific antigen expression. Conclusions: Occult lymph node metastases can be detected in a substantial proportion of patients with stage pT3NO prostate cancer, are associated with known predictors of disease progression, and may be useful in identifying patients at risk for recurrence and progression.

Original language	English
Pages (from-to)	474-478
Number of pages	5
Journal	The Journal of urology
Volume	154
Issue number	2
DOIs	https://doi.org/10.1016/S0022-5347(01)67077-0
State	Published - Aug 1995

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title = "Incidence of Occult Lymph Node Metastases in Pathological Stage C (pT3NO) Prostate Cancer",

abstract = "Purpose: To determine the incidence of occult lymph node metastases in patients with stage pT3NO prostate cancer. Materials and Methods: Lymph nodes from 95 patients with stage pT3NO prostate cancer were analyzed by immunohistochemistry for extrinsic epithelial cells using epithelial-specific monoclonal antibodies. The extrinsic epithelial cells were also tested for prostate specific antigen expression. Results: Occult lymph node metastases were identified in 15 cases (16 percent) and were more frequent in patients with high primary Gleason grade tumors and seminal vesicle invasion (p = 0.03). In all cases the extrinsic cells were of prostate origin based on prostate specific antigen expression. Conclusions: Occult lymph node metastases can be detected in a substantial proportion of patients with stage pT3NO prostate cancer, are associated with known predictors of disease progression, and may be useful in identifying patients at risk for recurrence and progression.",

author = "Freeman, {John A.} and David Esrig and Grossfeld, {Gary D.} and Stein, {John P.} and Chen Su-Chiu and Young, {Lillian L.} and Taylor, {Clive R.} and Skinner, {Donald G.} and Gary Lieskovsky and Cote, {Richard J.}",

year = "1995",

month = aug,

doi = "10.1016/S0022-5347(01)67077-0",

language = "English",

volume = "154",

pages = "474--478",

journal = "The Journal of urology",

issn = "0022-5347",

number = "2",

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TY - JOUR

T1 - Incidence of Occult Lymph Node Metastases in Pathological Stage C (pT3NO) Prostate Cancer

AU - Freeman, John A.

AU - Esrig, David

AU - Grossfeld, Gary D.

AU - Stein, John P.

AU - Su-Chiu, Chen

AU - Young, Lillian L.

AU - Taylor, Clive R.

AU - Skinner, Donald G.

AU - Lieskovsky, Gary

AU - Cote, Richard J.

PY - 1995/8

Y1 - 1995/8

N2 - Purpose: To determine the incidence of occult lymph node metastases in patients with stage pT3NO prostate cancer. Materials and Methods: Lymph nodes from 95 patients with stage pT3NO prostate cancer were analyzed by immunohistochemistry for extrinsic epithelial cells using epithelial-specific monoclonal antibodies. The extrinsic epithelial cells were also tested for prostate specific antigen expression. Results: Occult lymph node metastases were identified in 15 cases (16 percent) and were more frequent in patients with high primary Gleason grade tumors and seminal vesicle invasion (p = 0.03). In all cases the extrinsic cells were of prostate origin based on prostate specific antigen expression. Conclusions: Occult lymph node metastases can be detected in a substantial proportion of patients with stage pT3NO prostate cancer, are associated with known predictors of disease progression, and may be useful in identifying patients at risk for recurrence and progression.

AB - Purpose: To determine the incidence of occult lymph node metastases in patients with stage pT3NO prostate cancer. Materials and Methods: Lymph nodes from 95 patients with stage pT3NO prostate cancer were analyzed by immunohistochemistry for extrinsic epithelial cells using epithelial-specific monoclonal antibodies. The extrinsic epithelial cells were also tested for prostate specific antigen expression. Results: Occult lymph node metastases were identified in 15 cases (16 percent) and were more frequent in patients with high primary Gleason grade tumors and seminal vesicle invasion (p = 0.03). In all cases the extrinsic cells were of prostate origin based on prostate specific antigen expression. Conclusions: Occult lymph node metastases can be detected in a substantial proportion of patients with stage pT3NO prostate cancer, are associated with known predictors of disease progression, and may be useful in identifying patients at risk for recurrence and progression.

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JO - The Journal of urology

JF - The Journal of urology

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ER -

Incidence of Occult Lymph Node Metastases in Pathological Stage C (pT3NO) Prostate Cancer

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